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Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.
Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M, Porzio O, Hribal ML, Folli F, Khokha R, Urbani A, Lauro R, Pugliese G, Federici M. Menghini R, et al. Among authors: lauro r. Gastroenterology. 2009 Feb;136(2):663-72.e4. doi: 10.1053/j.gastro.2008.10.079. Epub 2008 Nov 6. Gastroenterology. 2009. PMID: 19027012
Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice.
Casagrande V, Menghini R, Menini S, Marino A, Marchetti V, Cavalera M, Fabrizi M, Hribal ML, Pugliese G, Gentileschi P, Schillaci O, Porzio O, Lauro D, Sbraccia P, Lauro R, Federici M. Casagrande V, et al. Among authors: lauro r, lauro d. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):74-81. doi: 10.1161/ATVBAHA.111.238402. Epub 2011 Oct 20. Arterioscler Thromb Vasc Biol. 2012. PMID: 22015660
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
Menghini R, Casagrande V, Menini S, Marino A, Marzano V, Hribal ML, Gentileschi P, Lauro D, Schillaci O, Pugliese G, Sbraccia P, Urbani A, Lauro R, Federici M. Menghini R, et al. Among authors: lauro r, lauro d. Diabetes. 2012 Feb;61(2):454-62. doi: 10.2337/db11-0613. Epub 2012 Jan 6. Diabetes. 2012. PMID: 22228717 Free PMC article.
The role of ADAM17 in metabolic inflammation.
Menghini R, Fiorentino L, Casagrande V, Lauro R, Federici M. Menghini R, et al. Among authors: lauro r. Atherosclerosis. 2013 May;228(1):12-7. doi: 10.1016/j.atherosclerosis.2013.01.024. Epub 2013 Jan 25. Atherosclerosis. 2013. PMID: 23384719 Review.
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
Fiorentino L, Cavalera M, Menini S, Marchetti V, Mavilio M, Fabrizi M, Conserva F, Casagrande V, Menghini R, Pontrelli P, Arisi I, D'Onofrio M, Lauro D, Khokha R, Accili D, Pugliese G, Gesualdo L, Lauro R, Federici M. Fiorentino L, et al. Among authors: lauro r, lauro d. EMBO Mol Med. 2013 Mar;5(3):441-55. doi: 10.1002/emmm.201201475. Epub 2013 Feb 12. EMBO Mol Med. 2013. PMID: 23401241 Free PMC article.
IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.
Fabrizi M, Marchetti V, Mavilio M, Marino A, Casagrande V, Cavalera M, Moreno-Navarrete JM, Mezza T, Sorice GP, Fiorentino L, Menghini R, Lauro R, Monteleone G, Giaccari A, Fernandez Real JM, Federici M. Fabrizi M, et al. Among authors: lauro r. Diabetes. 2014 Jun;63(6):2086-96. doi: 10.2337/db13-0939. Epub 2014 Jan 15. Diabetes. 2014. PMID: 24430438
ITCH deficiency protects from diet-induced obesity.
Marino A, Menghini R, Fabrizi M, Casagrande V, Mavilio M, Stoehr R, Candi E, Mauriello A, Moreno-Navarrete JM, Gómez-Serrano M, Peral B, Melino G, Lauro R, Fernandez Real JM, Federici M. Marino A, et al. Among authors: lauro r. Diabetes. 2014 Feb;63(2):550-61. doi: 10.2337/db13-0802. Epub 2013 Oct 29. Diabetes. 2014. PMID: 24170694
392 results