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Expression of p89(c-Mybex9b), an alternatively spliced form of c-Myb, is required for proliferation and survival of p210BCR/ABL-expressing cells.
Manzotti G, Mariani SA, Corradini F, Bussolari R, Cesi V, Vergalli J, Ferrari-Amorotti G, Fragliasso V, Soliera AR, Cattelani S, Raschellà G, Holyoake TL, Calabretta B. Manzotti G, et al. Among authors: holyoake tl. Blood Cancer J. 2012 May;2(5):e71. doi: 10.1038/bcj.2012.16. Epub 2012 May 11. Blood Cancer J. 2012. PMID: 22829973 Free PMC article.
Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.
Soliera AR, Mariani SA, Audia A, Lidonnici MR, Addya S, Ferrari-Amorotti G, Cattelani S, Manzotti G, Fragliasso V, Peterson L, Perini G, Holyoake TL, Calabretta B. Soliera AR, et al. Among authors: holyoake tl. Leukemia. 2012 Jul;26(7):1555-63. doi: 10.1038/leu.2012.19. Epub 2012 Jan 30. Leukemia. 2012. PMID: 22285998 Free PMC article.
Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells.
Lidonnici MR, Audia A, Soliera AR, Prisco M, Ferrari-Amorotti G, Waldron T, Donato N, Zhang Y, Martinez RV, Holyoake TL, Calabretta B. Lidonnici MR, et al. Among authors: holyoake tl. Cancer Res. 2010 Oct 15;70(20):7949-59. doi: 10.1158/0008-5472.CAN-10-1667. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924107 Free PMC article.
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirrò E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B. Bellodi C, et al. J Clin Invest. 2009 May;119(5):1109-23. doi: 10.1172/JCI35660. Epub 2009 Apr 13. J Clin Invest. 2009. PMID: 19363292 Free PMC article.
Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition.
Mitchell R, Hopcroft LEM, Baquero P, Allan EK, Hewit K, James D, Hamilton G, Mukhopadhyay A, O'Prey J, Hair A, Melo JV, Chan E, Ryan KM, Maguer-Satta V, Druker BJ, Clark RE, Mitra S, Herzyk P, Nicolini FE, Salomoni P, Shanks E, Calabretta B, Holyoake TL, Helgason GV. Mitchell R, et al. Among authors: holyoake tl. J Natl Cancer Inst. 2018 May 1;110(5):467-478. doi: 10.1093/jnci/djx236. J Natl Cancer Inst. 2018. PMID: 29165716 Free PMC article.
BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells.
Schemionek M, Elling C, Steidl U, Bäumer N, Hamilton A, Spieker T, Göthert JR, Stehling M, Wagers A, Huettner CS, Tenen DG, Tickenbrock L, Berdel WE, Serve H, Holyoake TL, Müller-Tidow C, Koschmieder S. Schemionek M, et al. Among authors: holyoake tl. Blood. 2010 Apr 22;115(16):3185-95. doi: 10.1182/blood-2009-04-215376. Epub 2010 Jan 6. Blood. 2010. PMID: 20053753 Free PMC article.
215 results