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Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia.
Gomes C, Ferreira R, George J, Sanches R, Rodrigues DI, Gonçalves N, Cunha RA. Gomes C, et al. Among authors: goncalves n. J Neuroinflammation. 2013 Jan 30;10:16. doi: 10.1186/1742-2094-10-16. J Neuroinflammation. 2013. PMID: 23363775 Free PMC article.
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
Viana da Silva S, Haberl MG, Zhang P, Bethge P, Lemos C, Gonçalves N, Gorlewicz A, Malezieux M, Gonçalves FQ, Grosjean N, Blanchet C, Frick A, Nägerl UV, Cunha RA, Mulle C. Viana da Silva S, et al. Among authors: goncalves n, goncalves fq. Nat Commun. 2016 Jun 17;7:11915. doi: 10.1038/ncomms11915. Nat Commun. 2016. PMID: 27312972 Free PMC article.
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.
Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Köfalvi A, Agostinho P, Cunha RA. Canas PM, et al. Among authors: goncalves n, goncalves fq. eNeuro. 2018 Dec 26;5(6):ENEURO.0385-18.2018. doi: 10.1523/ENEURO.0385-18.2018. eCollection 2018 Nov-Dec. eNeuro. 2018. PMID: 30627646 Free PMC article.
Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine.
Gonçalves FQ, Lopes JP, Silva HB, Lemos C, Silva AC, Gonçalves N, Tomé ÂR, Ferreira SG, Canas PM, Rial D, Agostinho P, Cunha RA. Gonçalves FQ, et al. Among authors: goncalves n. Neurobiol Dis. 2019 Dec;132:104570. doi: 10.1016/j.nbd.2019.104570. Epub 2019 Aug 5. Neurobiol Dis. 2019. PMID: 31394204 Free article.
405 results