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Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells.
Silva-Neto JP, Barreto RA, Pitanga BP, Souza CS, Silva VD, Silva AR, Velozo ES, Cunha SD, Batatinha MJ, Tardy M, Ribeiro CS, Costa MF, El-Bachá RS, Costa SL. Silva-Neto JP, et al. Among authors: costa mf, costa sl. Toxicon. 2010 Jan;55(1):105-17. doi: 10.1016/j.toxicon.2009.07.007. Epub 2009 Jul 15. Toxicon. 2010. PMID: 19615397
Juliprosopine and juliprosine from prosopis juliflora leaves induce mitochondrial damage and cytoplasmic vacuolation on cocultured glial cells and neurons.
Silva VD, Pitanga BP, Nascimento RP, Souza CS, Coelho PL, Menezes-Filho N, Silva AM, Costa Mde F, El-Bachá RS, Velozo ES, Costa SL. Silva VD, et al. Among authors: costa sl, costa mde f. Chem Res Toxicol. 2013 Dec 16;26(12):1810-20. doi: 10.1021/tx4001573. Epub 2013 Dec 6. Chem Res Toxicol. 2013. PMID: 23923817
Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
Santos BL, Oliveira MN, Coelho PL, Pitanga BP, da Silva AB, Adelita T, Silva VD, Costa Mde F, El-Bachá RS, Tardy M, Chneiweiss H, Junier MP, Moura-Neto V, Costa SL. Santos BL, et al. Among authors: costa sl, costa mde f. Chem Biol Interact. 2015 Dec 5;242:123-38. doi: 10.1016/j.cbi.2015.07.014. Epub 2015 Sep 25. Chem Biol Interact. 2015. PMID: 26408079
Aminochrome induces microglia and astrocyte activation.
Santos CC, Araújo FM, Ferreira RS, Silva VB, Silva JHC, Grangeiro MS, Soares ÉN, Pereira ÉPL, Souza CS, Costa SL, Segura-Aguilar J, Silva VDA. Santos CC, et al. Among authors: costa sl. Toxicol In Vitro. 2017 Aug;42:54-60. doi: 10.1016/j.tiv.2017.04.004. Epub 2017 Apr 6. Toxicol In Vitro. 2017. PMID: 28392416 Free article.
Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.
de Araújo FM, Ferreira RS, Souza CS, Dos Santos CC, Rodrigues TLRS, E Silva JHC, Gasparotto J, Gelain DP, El-Bachá RS, D Costa MF, Fonseca JCM, Segura-Aguilar J, Costa SL, Silva VDA. de Araújo FM, et al. Among authors: costa sl. Neurotoxicology. 2018 May;66:98-106. doi: 10.1016/j.neuro.2018.03.009. Epub 2018 Mar 26. Neurotoxicology. 2018. PMID: 29588162 Free article.
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: costa sl. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
127 results