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Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N, Sekiguchi S, Ishige T, Shima K, Nabeno M, Abe Y, Anabuki J, Soejima A, Yoshida K, Takashina Y, Ishii S, Kiuchi S, Fukuda S, Tsutsumiuchi R, Kosaka K, Murozono T, Nakamaru Y, Utsumi H, Masutomi N, Kishida H, Miyaguchi I, Hayashi Y. Yoshida T, et al. Among authors: kiuchi s. Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. doi: 10.1016/j.bmc.2012.08.012. Epub 2012 Aug 17. Bioorg Med Chem. 2012. PMID: 22959556
Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor.
Watanabe Y, Asai H, Ishii T, Kiuchi S, Okamoto M, Taniguchi H, Nagasaki M, Saito A. Watanabe Y, et al. Among authors: kiuchi s. J Pharmacol Sci. 2008 Jan;106(1):121-7. doi: 10.1254/jphs.fp0071400. Epub 2008 Jan 11. J Pharmacol Sci. 2008. PMID: 18187929 Free article.
Reappraisal of serum retinol-binding protein as a surrogate marker for retinol and discovery of a novel retinol estimation formula.
Matsuki Y, Ichihara K, Itoh Y, Mori K, Ihara H, Maekawa M, Nishimura M, Kiuchi S, Nomura F, Hashizume N, Itoh N, Matsumura S; Japan Society of Clinical Chemistry, Nutrition Committee. Matsuki Y, et al. Among authors: kiuchi s. Clin Nutr ESPEN. 2024 Jun;61:119-130. doi: 10.1016/j.clnesp.2024.03.017. Epub 2024 Mar 13. Clin Nutr ESPEN. 2024. PMID: 38777423 Free article.
185 results