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Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.
Pharmaceuticals (Basel). 2011 Oct 13;4(10):1328-1354. doi: 10.3390/ph4101328.
Pharmaceuticals (Basel). 2011.
PMID: 23115527
Free PMC article.
Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase.
Ahmad MF, Kaushal PS, Wan Q, Wijerathna SR, An X, Huang M, Dealwis CG.
Ahmad MF, et al. Among authors: wijerathna sr.
J Mol Biol. 2012 Jun 22;419(5):315-29. doi: 10.1016/j.jmb.2012.03.014. Epub 2012 Mar 29.
J Mol Biol. 2012.
PMID: 22465672
Free PMC article.
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The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore.
Xu H, Fairman JW, Wijerathna SR, Kreischer NR, LaMacchia J, Helmbrecht E, Cooperman BS, Dealwis C.
Xu H, et al. Among authors: wijerathna sr.
J Med Chem. 2008 Aug 14;51(15):4653-9. doi: 10.1021/jm800350u. Epub 2008 Jul 9.
J Med Chem. 2008.
PMID: 18610997
Free PMC article.
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Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme.
Misko TA, Wijerathna SR, Radivoyevitch T, Berdis AJ, Ahmad MF, Harris ME, Dealwis CG.
Misko TA, et al. Among authors: wijerathna sr.
FEBS Lett. 2016 Jun;590(12):1704-12. doi: 10.1002/1873-3468.12207. Epub 2016 May 27.
FEBS Lett. 2016.
PMID: 27155231
Free PMC article.
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Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG.
Fairman JW, et al. Among authors: wijerathna sr.
Nat Struct Mol Biol. 2011 Mar;18(3):316-22. doi: 10.1038/nsmb.2007. Epub 2011 Feb 20.
Nat Struct Mol Biol. 2011.
PMID: 21336276
Free PMC article.
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Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors.
Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE.
Sun D, et al. Among authors: wijerathna sr.
ChemMedChem. 2009 Oct;4(10):1649-56. doi: 10.1002/cmdc.200900236.
ChemMedChem. 2009.
PMID: 19681093
Free PMC article.
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