Rea D - Search Results

1

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.

Van der Veken P, Fülöp V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K. Van der Veken P, et al. Among authors: rea d. J Med Chem. 2012 Nov 26;55(22):9856-67. doi: 10.1021/jm301060g. Epub 2012 Nov 13. J Med Chem. 2012. PMID: 23121075

2

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling.

Rea D, Van Elzen R, De Winter H, Van Goethem S, Landuyt B, Luyten W, Schoofs L, Van Der Veken P, Augustyns K, De Meester I, Fülöp V, Lambeir AM. Rea D, et al. Eur J Med Chem. 2017 Oct 20;139:482-491. doi: 10.1016/j.ejmech.2017.08.024. Epub 2017 Aug 10. Eur J Med Chem. 2017. PMID: 28826083

3

Structure-function properties of prolyl oligopeptidase family enzymes.

Rea D, Fülöp V. Rea D, et al. Cell Biochem Biophys. 2006;44(3):349-65. doi: 10.1385/CBB:44:3:349. Cell Biochem Biophys. 2006. PMID: 16679522 Review.

4

Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide.

Racys DT, Rea D, Fülöp V, Wills M. Racys DT, et al. Among authors: rea d. Bioorg Med Chem. 2010 Jul 1;18(13):4775-82. doi: 10.1016/j.bmc.2010.05.012. Epub 2010 May 31. Bioorg Med Chem. 2010. PMID: 20627594

5

Prolyl oligopeptidase structure and dynamics.

Rea D, Fülöp V. Rea D, et al. CNS Neurol Disord Drug Targets. 2011 May;10(3):306-10. doi: 10.2174/187152711794653850. CNS Neurol Disord Drug Targets. 2011. PMID: 21222626 Review.

6

Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme.

Lambeir AM, Rea D, Fülöp V, Kumagai Y, Augustyns K, de Meester I, Haemers A, Scharpé S. Lambeir AM, et al. Among authors: rea d. Adv Exp Med Biol. 2003;524:29-35. doi: 10.1007/0-306-47920-6_3. Adv Exp Med Biol. 2003. PMID: 12675220 No abstract available.

7

Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes.

Canning P, Rea D, Morty RE, Fülöp V. Canning P, et al. Among authors: rea d. PLoS One. 2013 Nov 12;8(11):e79349. doi: 10.1371/journal.pone.0079349. eCollection 2013. PLoS One. 2013. PMID: 24265767 Free PMC article.

8

Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site.

Szeltner Z, Rea D, Renner V, Fulop V, Polgar L. Szeltner Z, et al. Among authors: rea d. J Biol Chem. 2002 Nov 8;277(45):42613-22. doi: 10.1074/jbc.M208043200. Epub 2002 Aug 28. J Biol Chem. 2002. PMID: 12202494 Free article.

9

Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding.

Szeltner Z, Rea D, Renner V, Juliano L, Fülop V, Polgár L. Szeltner Z, et al. Among authors: rea d. J Biol Chem. 2003 Dec 5;278(49):48786-93. doi: 10.1074/jbc.M309555200. Epub 2003 Sep 25. J Biol Chem. 2003. PMID: 14514675 Free article.

10

Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.

Szeltner Z, Rea D, Juhász T, Renner V, Mucsi Z, Orosz G, Fülöp V, Polgár L. Szeltner Z, et al. Among authors: rea d. J Biol Chem. 2002 Nov 22;277(47):44597-605. doi: 10.1074/jbc.M207386200. Epub 2002 Sep 11. J Biol Chem. 2002. PMID: 12228249 Free article.

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