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P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.
Van der Veken P, Fülöp V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K. Van der Veken P, et al. Among authors: van elzen r. J Med Chem. 2012 Nov 26;55(22):9856-67. doi: 10.1021/jm301060g. Epub 2012 Nov 13. J Med Chem. 2012. PMID: 23121075
Development of potent and selective dipeptidyl peptidase II inhibitors.
Senten K, Van der Veken P, Bal G, De Meester I, Lambeir AM, Scharpé S, Bauvois B, Haemers A, Augustyns K. Senten K, et al. Among authors: van der veken p. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2825-8. doi: 10.1016/s0960-894x(02)00603-0. Bioorg Med Chem Lett. 2002. PMID: 12270155
Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7).
Maes MB, Lambeir AM, Gilany K, Senten K, Van der Veken P, Leiting B, Augustyns K, Scharpé S, De Meester I. Maes MB, et al. Among authors: van der veken p. Biochem J. 2005 Mar 1;386(Pt 2):315-24. doi: 10.1042/BJ20041156. Biochem J. 2005. PMID: 15487984 Free PMC article.
158 results