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EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay.
Kroeger T, Frieg B, Zhang T, Hansen FK, Marmann A, Proksch P, Nagel-Steger L, Groth G, Smits SHJ, Gohlke H. Kroeger T, et al. Among authors: gohlke h. PLoS One. 2017 May 4;12(5):e0177024. doi: 10.1371/journal.pone.0177024. eCollection 2017. PLoS One. 2017. PMID: 28472107 Free PMC article.
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.
Krieger V, Hamacher A, Gertzen CGW, Senger J, Zwinderman MRH, Marek M, Romier C, Dekker FJ, Kurz T, Jung M, Gohlke H, Kassack MU, Hansen FK. Krieger V, et al. Among authors: gohlke h. J Med Chem. 2017 Jul 13;60(13):5493-5506. doi: 10.1021/acs.jmedchem.7b00197. Epub 2017 Jun 16. J Med Chem. 2017. PMID: 28574690
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.
Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J. Bhatia S, et al. Among authors: gohlke h. Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. Epub 2018 May 3. Blood. 2018. PMID: 29724897 Free PMC article.
397 results