Edelmann W - Search Results

1

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.

Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM Jr, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF. Bothmer A, et al. Among authors: edelmann w. J Exp Med. 2013 Jan 14;210(1):115-23. doi: 10.1084/jem.20121975. Epub 2012 Dec 17. J Exp Med. 2013. PMID: 23254285 Free PMC article.

2

The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.

Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S. Chahwan R, et al. Among authors: edelmann w. J Exp Med. 2012 Apr 9;209(4):671-8. doi: 10.1084/jem.20111531. Epub 2012 Mar 26. J Exp Med. 2012. PMID: 22451719 Free PMC article.

3

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.

Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W. Schaetzlein S, et al. Among authors: edelmann w. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9. doi: 10.1073/pnas.1308512110. Epub 2013 Jun 10. Proc Natl Acad Sci U S A. 2013. PMID: 23754438 Free PMC article.

4

The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair.

van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W. van Oers JM, et al. Among authors: edelmann w. Oncogene. 2014 Jul 24;33(30):3939-46. doi: 10.1038/onc.2013.365. Epub 2013 Sep 9. Oncogene. 2014. PMID: 24013230 Free PMC article.

5

Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.

Tosti E, Katakowski JA, Schaetzlein S, Kim HS, Ryan CJ, Shales M, Roguev A, Krogan NJ, Palliser D, Keogh MC, Edelmann W. Tosti E, et al. Among authors: edelmann w. Genome Med. 2014 Sep 17;6(9):68. doi: 10.1186/s13073-014-0068-4. eCollection 2014. Genome Med. 2014. PMID: 25302077 Free PMC article.

6

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.

Schrader CE, Edelmann W, Kucherlapati R, Stavnezer J. Schrader CE, et al. Among authors: edelmann w. J Exp Med. 1999 Aug 2;190(3):323-30. doi: 10.1084/jem.190.3.323. J Exp Med. 1999. PMID: 10430621 Free PMC article.

7

Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification.

Li Z, Scherer SJ, Ronai D, Iglesias-Ussel MD, Peled JU, Bardwell PD, Zhuang M, Lee K, Martin A, Edelmann W, Scharff MD. Li Z, et al. Among authors: edelmann w. J Exp Med. 2004 Jul 5;200(1):47-59. doi: 10.1084/jem.20040355. J Exp Med. 2004. PMID: 15238604 Free PMC article.

8

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination.

Martin A, Li Z, Lin DP, Bardwell PD, Iglesias-Ussel MD, Edelmann W, Scharff MD. Martin A, et al. Among authors: edelmann w. J Exp Med. 2003 Oct 20;198(8):1171-8. doi: 10.1084/jem.20030880. J Exp Med. 2003. PMID: 14568978 Free PMC article.

9

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

Will B, Vogler TO, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Neriah DB, Roth M, van Oers J, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U. Will B, et al. Among authors: edelmann w. Nat Med. 2015 Oct;21(10):1172-81. doi: 10.1038/nm.3936. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343801 Free PMC article.

10

Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.

Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M. Di Giacomo M, et al. Among authors: edelmann w. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):737-42. doi: 10.1073/pnas.0406212102. Epub 2005 Jan 7. Proc Natl Acad Sci U S A. 2005. PMID: 15640358 Free PMC article.

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