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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.
Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ. Bull KR, et al. Among authors: siggs om. PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31. PLoS Genet. 2013. PMID: 23382690 Free PMC article.
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.
Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B, Cornall RJ. Siggs OM, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3706-15. doi: 10.1073/pnas.1607592113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303042 Free PMC article.
The BTB-ZF transcription factors.
Siggs OM, Beutler B. Siggs OM, et al. Cell Cycle. 2012 Sep 15;11(18):3358-69. doi: 10.4161/cc.21277. Epub 2012 Aug 16. Cell Cycle. 2012. PMID: 22894929 Free PMC article. Review.
ZBTB1 is a determinant of lymphoid development.
Siggs OM, Li X, Xia Y, Beutler B. Siggs OM, et al. J Exp Med. 2012 Jan 16;209(1):19-27. doi: 10.1084/jem.20112084. Epub 2011 Dec 26. J Exp Med. 2012. PMID: 22201126 Free PMC article.
iRhom2 is required for the secretion of mouse TNFα.
Siggs OM, Xiao N, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B. Siggs OM, et al. Blood. 2012 Jun 14;119(24):5769-71. doi: 10.1182/blood-2012-03-417949. Epub 2012 May 1. Blood. 2012. PMID: 22550345 Free PMC article.
ENU-induced phenovariance in mice: inferences from 587 mutations.
Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B. Arnold CN, et al. Among authors: siggs om. BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577. BMC Res Notes. 2012. PMID: 23095377 Free PMC article.
91 results