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Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S. Wakabayashi M, et al. Among authors: nomura s, nomura n. Cell Rep. 2013 Mar 28;3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28. Cell Rep. 2013. PMID: 23453970 Free article.
WNK4 is the major WNK positively regulating NCC in the mouse kidney.
Takahashi D, Mori T, Nomura N, Khan MZ, Araki Y, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S. Takahashi D, et al. Among authors: nomura n. Biosci Rep. 2014 May 9;34(3):e00107. doi: 10.1042/BSR20140047. Biosci Rep. 2014. PMID: 24655003 Free PMC article.
Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E. Yoshizaki Y, et al. Among authors: nomura n. Biochem Biophys Res Commun. 2015 Nov 13;467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. Biochem Biophys Res Commun. 2015. PMID: 26435498
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.
Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E. Sasaki E, et al. Among authors: nomura n. Mol Cell Biol. 2017 Mar 17;37(7):e00508-16. doi: 10.1128/MCB.00508-16. Print 2017 Apr 1. Mol Cell Biol. 2017. PMID: 28052936 Free PMC article.
WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.
Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S. Takahashi D, et al. Among authors: nomura n. EBioMedicine. 2017 Apr;18:118-127. doi: 10.1016/j.ebiom.2017.03.011. Epub 2017 Mar 8. EBioMedicine. 2017. PMID: 28314693 Free PMC article.
Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.
Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E. Kasagi Y, et al. Among authors: nomura n. Biochem Biophys Res Commun. 2017 May 27;487(2):368-374. doi: 10.1016/j.bbrc.2017.04.068. Epub 2017 Apr 14. Biochem Biophys Res Commun. 2017. PMID: 28414128
894 results