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Growth factor independence 1 (Gfi1) as a regulator of p53 activity and a new therapeutical target for ALL.
Khandanpour C, Möröy T. Khandanpour C, et al. Oncotarget. 2013 Mar;4(3):374-5. doi: 10.18632/oncotarget.933. Oncotarget. 2013. PMID: 23528269 Free PMC article.
The transcriptional repressor Gfi1 can be a so-called "oncorequisite" factor that is required for the development and maintenance of lymphoid neoplasia, such as Acute Lymphoblastic Leukemia (ALL), but does not have a direct role in the ontogeny of the disease. The study supportin …
The transcriptional repressor Gfi1 can be a so-called "oncorequisite" factor that is required for the development and maintenance of lymphoi …
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.
Khandanpour C, Thiede C, Valk PJ, Sharif-Askari E, Nückel H, Lohmann D, Horsthemke B, Siffert W, Neubauer A, Grzeschik KH, Bloomfield CD, Marcucci G, Maharry K, Slovak ML, van der Reijden BA, Jansen JH, Schackert HK, Afshar K, Schnittger S, Peeters JK, Kroschinsky F, Ehninger G, Lowenberg B, Dührsen U, Möröy T. Khandanpour C, et al. Blood. 2010 Mar 25;115(12):2462-72. doi: 10.1182/blood-2009-08-239822. Epub 2010 Jan 14. Blood. 2010. PMID: 20075157 Free PMC article.
Origin of the brush cell lineage in the mouse intestinal epithelium.
Bjerknes M, Khandanpour C, Möröy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martín MG, Cheng H. Bjerknes M, et al. Among authors: khandanpour c. Dev Biol. 2012 Feb 15;362(2):194-218. doi: 10.1016/j.ydbio.2011.12.009. Epub 2011 Dec 13. Dev Biol. 2012. PMID: 22185794 Free PMC article.
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Gaudreau MC, Chen R, Calero-Nieto FJ, Diamanti E, Hannah R, Meyer SE, Grimes HL, van der Reijden BA, Jansen JH, Patel CV, Peeters JK, Löwenberg B, Dührsen U, Göttgens B, Möröy T. Khandanpour C, et al. Blood. 2012 Nov 8;120(19):4006-17. doi: 10.1182/blood-2011-02-334722. Epub 2012 Aug 28. Blood. 2012. PMID: 22932805 Free article.
66 results