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The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties.
Ferraro L, Loche A, Beggiato S, Tomasini MC, Antonelli T, Colombo G, Lobina C, Carai MA, Porcu A, Castelli MP, Clerici F, Borelli AC, Cacciaglia R, Tanganelli S. Ferraro L, et al. Among authors: cacciaglia r. Curr Med Chem. 2013;20(27):3339-57. doi: 10.2174/09298673113209990167. Curr Med Chem. 2013. PMID: 23862615 Review.
Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans.
Haass-Koffler CL, Goodyear K, Loche A, Long VM, Lobina C, Tran HH, Cacciaglia R, Swift RM, Colombo G, Leggio L. Haass-Koffler CL, et al. Among authors: cacciaglia r. J Psychopharmacol. 2018 Feb;32(2):163-173. doi: 10.1177/0269881117746904. Epub 2018 Jan 23. J Psychopharmacol. 2018. PMID: 29361897 Free PMC article. Clinical Trial.
A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers.
Haass-Koffler CL, Goodyear K, Long VM, Tran HH, Loche A, Cacciaglia R, Swift RM, Leggio L. Haass-Koffler CL, et al. Among authors: cacciaglia r. Eur J Pharm Sci. 2017 Nov 15;109:78-85. doi: 10.1016/j.ejps.2017.07.031. Epub 2017 Aug 1. Eur J Pharm Sci. 2017. PMID: 28778464 Free PMC article. Clinical Trial.
Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73.
Loche A, Simonetti F, Lobina C, Carai MA, Colombo G, Castelli MP, Barone D, Cacciaglia R. Loche A, et al. Among authors: cacciaglia r. Front Psychiatry. 2012 Feb 14;3:8. doi: 10.3389/fpsyt.2012.00008. eCollection 2012. Front Psychiatry. 2012. PMID: 22347868 Free PMC article.
Dataset for Phase I randomized clinical trial for safety and tolerability of GET 73 in single and repeated ascending doses including preliminary pharmacokinetic parameters.
Haass-Koffler CL, Goodyear K, Long VM, Tran HH, Loche A, Cacciaglia R, Swift RM, Leggio L. Haass-Koffler CL, et al. Among authors: cacciaglia r. Data Brief. 2017 Sep 17;15:407-413. doi: 10.1016/j.dib.2017.09.018. eCollection 2017 Dec. Data Brief. 2017. PMID: 29214202 Free PMC article.
An inpatient human laboratory study assessing the safety and tolerability, pharmacokinetics, and biobehavioral effect of GET 73 when co-administered with alcohol in individuals with alcohol use disorder.
Haass-Koffler CL, Perciballi R, Magill M, Loche A, Cacciaglia R, Leggio L, Swift RM. Haass-Koffler CL, et al. Among authors: cacciaglia r. Psychopharmacology (Berl). 2022 Jan;239(1):35-46. doi: 10.1007/s00213-021-06008-1. Epub 2021 Nov 3. Psychopharmacology (Berl). 2022. PMID: 34731268 Free PMC article. Clinical Trial.
Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial.
Guiraud J, Addolorato G, Antonelli M, Aubin HJ, de Bejczy A, Benyamina A, Cacciaglia R, Caputo F, Dematteis M, Ferrulli A, Goudriaan AE, Gual A, Lesch OM, Maremmani I, Mirijello A, Nutt DJ, Paille F, Perney P, Poulnais R, Raffaillac Q, Rehm J, Rolland B, Rotondo C, Scherrer B, Simon N, Skala K, Söderpalm B, Somaini L, Sommer WH, Spanagel R, Vassallo GA, Walter H, van den Brink W. Guiraud J, et al. Among authors: cacciaglia r. J Psychopharmacol. 2022 Oct;36(10):1136-1145. doi: 10.1177/02698811221104063. Epub 2022 Jul 7. J Psychopharmacol. 2022. PMID: 35796481 Free PMC article. Clinical Trial.
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