Hixon MS - Search Results

1

The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.

Silhár P, Lardy MA, Hixon MS, Shoemaker CB, Barbieri JT, Struss AK, Lively JM, Javor S, Janda KD. Silhár P, et al. Among authors: hixon ms. ACS Med Chem Lett. 2013 Feb 14;4(2):283-287. doi: 10.1021/ml300428s. Epub 2012 Dec 23. ACS Med Chem Lett. 2013. PMID: 23565325 Free PMC article.

2

Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library.

Dickerson TJ, Beuscher AE 4th, Rogers CJ, Hixon MS, Yamamoto N, Xu Y, Olson AJ, Janda KD. Dickerson TJ, et al. Among authors: hixon ms. Biochemistry. 2005 Nov 15;44(45):14845-53. doi: 10.1021/bi051613x. Biochemistry. 2005. PMID: 16274232

3

Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin.

McAllister LA, Hixon MS, Kennedy JP, Dickerson TJ, Janda KD. McAllister LA, et al. Among authors: hixon ms. J Am Chem Soc. 2006 Apr 5;128(13):4176-7. doi: 10.1021/ja057699z. J Am Chem Soc. 2006. PMID: 16568962 Free PMC article.

4

Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers.

Moss JA, Stokols S, Hixon MS, Ashley FT, Chang JY, Janda KD. Moss JA, et al. Among authors: hixon ms. Biomacromolecules. 2006 Apr;7(4):1011-6. doi: 10.1021/bm051001s. Biomacromolecules. 2006. PMID: 16602715 Free PMC article.

5

Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda KD. Boldt GE, et al. Among authors: hixon ms. J Comb Chem. 2006 Jul-Aug;8(4):513-21. doi: 10.1021/cc060010h. J Comb Chem. 2006. PMID: 16827563 Free PMC article.

6

Identification and characterization of single chain anti-cocaine catalytic antibodies.

McKenzie KM, Mee JM, Rogers CJ, Hixon MS, Kaufmann GF, Janda KD. McKenzie KM, et al. Among authors: hixon ms. J Mol Biol. 2007 Jan 19;365(3):722-31. doi: 10.1016/j.jmb.2006.10.031. Epub 2006 Nov 3. J Mol Biol. 2007. PMID: 17084858 Free PMC article.

7

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD. Eubanks LM, et al. Among authors: hixon ms. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2602-7. doi: 10.1073/pnas.0611213104. Epub 2007 Feb 9. Proc Natl Acad Sci U S A. 2007. PMID: 17293454 Free PMC article.

8

Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies.

McAllister LA, Hixon MS, Schwartz R, Kubitz DS, Janda KD. McAllister LA, et al. Among authors: hixon ms. Bioconjug Chem. 2007 Mar-Apr;18(2):559-66. doi: 10.1021/bc0602984. Epub 2007 Feb 22. Bioconjug Chem. 2007. PMID: 17315943

9

Antibody-catalyzed anaerobic destruction of methamphetamine.

Xu Y, Hixon MS, Yamamoto N, McAllister LA, Wentworth AD, Wentworth P Jr, Janda KD. Xu Y, et al. Among authors: hixon ms. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3681-6. doi: 10.1073/pnas.0611094104. Epub 2007 Feb 28. Proc Natl Acad Sci U S A. 2007. PMID: 17360412 Free PMC article.

10

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.

Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN. Silvaggi NR, et al. Among authors: hixon ms. Chem Biol. 2007 May;14(5):533-42. doi: 10.1016/j.chembiol.2007.03.014. Chem Biol. 2007. PMID: 17524984

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