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Systemic administration of radiation-potentiated anti-angiogenic gene therapy against primary and metastatic cancer based on transcriptionally controlled HSV-TK.
Hodish I, Tal R, Shaish A, Varda-Bloom N, Greenberger S, Rauchwerger A, Breitbart E, Bangio L, Ben-Shushan D, Pfeffer R, Feder B, Waitsman A, Barshack I, Goldberg I, Mazaki-Tovi S, Peled M, Harats D. Hodish I, et al. Among authors: harats d. Cancer Biol Ther. 2009 Mar;8(5):424-32. doi: 10.4161/cbt.8.5.7589. Epub 2009 Mar 19. Cancer Biol Ther. 2009. PMID: 19276657
Transcription-controlled gene therapy against tumor angiogenesis.
Greenberger S, Shaish A, Varda-Bloom N, Levanon K, Breitbart E, Goldberg I, Barshack I, Hodish I, Yaacov N, Bangio L, Goncharov T, Wallach D, Harats D. Greenberger S, et al. Among authors: harats d. J Clin Invest. 2004 Apr;113(7):1017-24. doi: 10.1172/JCI20007. J Clin Invest. 2004. PMID: 15057308 Free PMC article.
Antiangiogenic systemic gene therapy combined with doxorubicin administration induced caspase 8 and 9-mediated apoptosis in endothelial cells and an anti-metastasis effect.
Peled M, Shaish A, Greenberger S, Katav A, Hodish I, Ben-Shushan D, Barshack I, Mendel I, Frishman L, Tal R, Bangio L, Breitbart E, Harats D. Peled M, et al. Among authors: harats d. Cancer Gene Ther. 2008 Aug;15(8):535-42. doi: 10.1038/cgt.2008.20. Epub 2008 Apr 18. Cancer Gene Ther. 2008. PMID: 18421310
Ofranergene obadenovec (VB-111) in platinum-resistant ovarian cancer; favorable response rates in a phase I/II study are associated with an immunotherapeutic effect.
Arend RC, Beer HM, Cohen YC, Berlin S, Birrer MJ, Campos SM, Rachmilewitz Minei T, Harats D, Wall JA, Foxall ME, Penson RT. Arend RC, et al. Among authors: harats d. Gynecol Oncol. 2020 Jun;157(3):578-584. doi: 10.1016/j.ygyno.2020.02.034. Epub 2020 Apr 5. Gynecol Oncol. 2020. PMID: 32265057 Free article. Clinical Trial.
201 results