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Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Nakamura Y, Fujimoto T, Ogawa Y, Namiki H, Suzuki S, Asano M, Sugita C, Mochizuki A, Miyazaki S, Tamaki K, Nagai Y, Inoue S, Nagayama T, Kato M, Chiba K, Takasuna K, Nishi T. Nakamura Y, et al. Among authors: sugita c. Bioorg Med Chem. 2013 Jun 1;21(11):3175-96. doi: 10.1016/j.bmc.2013.03.022. Epub 2013 Mar 26. Bioorg Med Chem. 2013. PMID: 23598247
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.
Mori Y, Ogawa Y, Mochizuki A, Nakamura Y, Sugita C, Miyazaki S, Tamaki K, Matsui Y, Takahashi M, Nagayama T, Nagai Y, Inoue S, Nishi T. Mori Y, et al. Among authors: sugita c. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7677-82. doi: 10.1016/j.bmcl.2012.09.103. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23122821
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
Nakamura Y, Fujimoto T, Ogawa Y, Sugita C, Miyazaki S, Tamaki K, Takahashi M, Matsui Y, Nagayama T, Manabe K, Mizuno M, Masubuchi N, Chiba K, Nishi T. Nakamura Y, et al. Among authors: sugita c. ACS Med Chem Lett. 2012 Aug 18;3(9):754-8. doi: 10.1021/ml300168e. eCollection 2012 Sep 13. ACS Med Chem Lett. 2012. PMID: 24900544 Free PMC article.
ED50 and ED95 of rocuronium during alfaxalone anesthesia in dogs.
Chen IY, Sugita C, Wei Y, Daimaruya N, Itami T, Sano T, Yamashita K. Chen IY, et al. Among authors: sugita c. Vet Anaesth Analg. 2023 May;50(3):204-210. doi: 10.1016/j.vaa.2023.02.008. Epub 2023 Feb 17. Vet Anaesth Analg. 2023. PMID: 36967325
86 results