Ottmann C - Search Results

1

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.

Anders C, Higuchi Y, Koschinsky K, Bartel M, Schumacher B, Thiel P, Nitta H, Preisig-Müller R, Schlichthörl G, Renigunta V, Ohkanda J, Daut J, Kato N, Ottmann C. Anders C, et al. Among authors: ottmann c. Chem Biol. 2013 Apr 18;20(4):583-93. doi: 10.1016/j.chembiol.2013.03.015. Chem Biol. 2013. PMID: 23601647

2

A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A.

Ottmann C, Weyand M, Sassa T, Inoue T, Kato N, Wittinghofer A, Oecking C. Ottmann C, et al. J Mol Biol. 2009 Mar 6;386(4):913-9. doi: 10.1016/j.jmb.2009.01.005. J Mol Biol. 2009. PMID: 19244612

3

Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.

Schumacher B, Mondry J, Thiel P, Weyand M, Ottmann C. Schumacher B, et al. Among authors: ottmann c. FEBS Lett. 2010 Apr 16;584(8):1443-8. doi: 10.1016/j.febslet.2010.02.065. Epub 2010 Mar 3. FEBS Lett. 2010. PMID: 20206173 Free article.

4

Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.

Molzan M, Schumacher B, Ottmann C, Baljuls A, Polzien L, Weyand M, Thiel P, Rose R, Rose M, Kuhenne P, Kaiser M, Rapp UR, Kuhlmann J, Ottmann C. Molzan M, et al. Among authors: ottmann c. Mol Cell Biol. 2010 Oct;30(19):4698-711. doi: 10.1128/MCB.01636-09. Epub 2010 Aug 2. Mol Cell Biol. 2010. PMID: 20679480 Free PMC article.

5

Structure of a 14-3-3σ-YAP phosphopeptide complex at 1.15 A resolution.

Schumacher B, Skwarczynska M, Rose R, Ottmann C. Schumacher B, et al. Among authors: ottmann c. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):978-84. doi: 10.1107/S1744309110025479. Epub 2010 Aug 21. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20823509 Free PMC article.

6

Structural insights of the MLF1/14-3-3 interaction.

Molzan M, Weyand M, Rose R, Ottmann C. Molzan M, et al. Among authors: ottmann c. FEBS J. 2012 Feb;279(4):563-71. doi: 10.1111/j.1742-4658.2011.08445.x. Epub 2012 Jan 9. FEBS J. 2012. PMID: 22151054 Free article.

7

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

Thiel P, Kaiser M, Ottmann C. Thiel P, et al. Among authors: ottmann c. Angew Chem Int Ed Engl. 2012 Feb 27;51(9):2012-8. doi: 10.1002/anie.201107616. Epub 2012 Feb 3. Angew Chem Int Ed Engl. 2012. PMID: 22308055 Review.

8

An optimised small-molecule stabiliser of the 14-3-3-PMA2 protein-protein interaction.

Richter A, Rose R, Hedberg C, Waldmann H, Ottmann C. Richter A, et al. Among authors: ottmann c. Chemistry. 2012 May 21;18(21):6520-7. doi: 10.1002/chem.201103761. Epub 2012 Mar 29. Chemistry. 2012. PMID: 22467351

9

Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins.

Röglin L, Thiel P, Kohlbacher O, Ottmann C. Röglin L, et al. Among authors: ottmann c. Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1051-3; author reply E1054. doi: 10.1073/pnas.1116592109. Epub 2012 Apr 24. Proc Natl Acad Sci U S A. 2012. PMID: 22532669 Free PMC article. No abstract available.

10

Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.

Rose R, Rose M, Ottmann C. Rose R, et al. Among authors: ottmann c. J Struct Biol. 2012 Oct;180(1):65-72. doi: 10.1016/j.jsb.2012.05.010. Epub 2012 May 24. J Struct Biol. 2012. PMID: 22634725

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