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Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71.
Wu C, Zhang L, Li P, Cai Q, Peng X, Yin K, Chen X, Ren H, Zhong S, Weng Y, Guan Y, Chen S, Wu J, Li J, Lin T. Wu C, et al. Among authors: chen s, chen x. Biochim Biophys Acta. 2016 Jun;1860(6):1299-307. doi: 10.1016/j.bbagen.2016.03.017. Epub 2016 Mar 15. Biochim Biophys Acta. 2016. PMID: 26987809
Design, synthesis, and biological evaluation of anti-EV71 agents.
Li P, Yang B, Hao F, Wang P, He H, Huang L, Zhang X, Zhang S, Peng X, Yin K, Hu J, Chen X, Gu Z, Wang L, Shen L, Hu G, Li N, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Zhang L, Cai Q, Lin T. Li P, et al. Among authors: chen s, chen x. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3346-3350. doi: 10.1016/j.bmcl.2016.05.036. Epub 2016 May 14. Bioorg Med Chem Lett. 2016. PMID: 27234148
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.
Li P, Yu J, Hao F, He H, Shi X, Hu J, Wang L, Du C, Zhang X, Sun Y, Lin F, Gu Z, Xu D, Chen X, Shen L, Hu G, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Tian X, Lin T. Li P, et al. Among authors: chen s, chen x. ACS Med Chem Lett. 2017 Jul 10;8(8):841-846. doi: 10.1021/acsmedchemlett.7b00188. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835799 Free PMC article.
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Li P, Wu S, Xiao T, Li Y, Su Z, Wei W, Hao F, Hu G, Lin F, Chen X, Gu Z, Lin T, He H, Li J, Chen S. Li P, et al. Among authors: chen s, chen x. Bioorg Med Chem. 2020 Jun 15;28(12):115551. doi: 10.1016/j.bmc.2020.115551. Epub 2020 May 8. Bioorg Med Chem. 2020. PMID: 32503695
HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.
Fang DD, Zhang B, Gu Q, Lira M, Xu Q, Sun H, Qian M, Sheng W, Ozeck M, Wang Z, Zhang C, Chen X, Chen KX, Li J, Chen SH, Christensen J, Mao M, Chan CC. Fang DD, et al. J Thorac Oncol. 2014 Mar;9(3):285-94. doi: 10.1097/JTO.0000000000000087. J Thorac Oncol. 2014. PMID: 24496003 Free article.
Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.
Wang J, Shen W, Yuan Z, Lan L, Xu J, Wang C, Ma G, Shi W, Han L, Zhang Z, Hou L, Shen L, Jiang Z, He H, Xiao W, Wang Z, Guo Q, Li J, Chen S. Wang J, et al. Among authors: chen s. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2844-8. doi: 10.1016/j.bmcl.2015.04.100. Epub 2015 May 11. Bioorg Med Chem Lett. 2015. PMID: 26009165
Discovery and optimization of selective RET inhibitors via scaffold hopping.
Luo Z, Wang L, Fu Z, Shuai B, Luo M, Hu G, Chen J, Sun J, Wang J, Li J, Chen S, Zhang Y. Luo Z, et al. Among authors: chen j, chen s. Bioorg Med Chem Lett. 2021 Sep 1;47:128149. doi: 10.1016/j.bmcl.2021.128149. Epub 2021 May 28. Bioorg Med Chem Lett. 2021. PMID: 34058344
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