Jenkins L - Search Results

1

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.

Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T. Christiansen E, et al. Among authors: jenkins l. ACS Med Chem Lett. 2013 May 9;4(5):441-445. doi: 10.1021/ml4000673. Epub 2013 Apr 8. ACS Med Chem Lett. 2013. PMID: 23687558 Free PMC article.

2

Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.

Canals M, Jenkins L, Kellett E, Milligan G. Canals M, et al. Among authors: jenkins l. J Biol Chem. 2006 Jun 16;281(24):16757-67. doi: 10.1074/jbc.M601121200. Epub 2006 Apr 11. J Biol Chem. 2006. PMID: 16611642 Free article.

3

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

Stoddart LA, Smith NJ, Jenkins L, Brown AJ, Milligan G. Stoddart LA, et al. Among authors: jenkins l. J Biol Chem. 2008 Nov 21;283(47):32913-24. doi: 10.1074/jbc.M805601200. Epub 2008 Sep 18. J Biol Chem. 2008. PMID: 18801738 Free article.

4

Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin.

Ward RJ, Jenkins L, Milligan G. Ward RJ, et al. Among authors: jenkins l. J Neurochem. 2009 Apr;109(1):182-92. doi: 10.1111/j.1471-4159.2009.05918.x. Epub 2009 Jan 23. J Neurochem. 2009. PMID: 19166508 Free article.

5

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.

Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G. Smith NJ, et al. Among authors: jenkins l. J Biol Chem. 2009 Jun 26;284(26):17527-39. doi: 10.1074/jbc.M109.012849. Epub 2009 Apr 27. J Biol Chem. 2009. PMID: 19398560 Free PMC article.

6

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G. Jenkins L, et al. Biochem J. 2010 Dec 15;432(3):451-9. doi: 10.1042/BJ20101287. Biochem J. 2010. PMID: 20919992

7

Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands.

Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Hudson BD, et al. Among authors: jenkins l. Mol Pharmacol. 2014 Aug;86(2):200-10. doi: 10.1124/mol.114.093294. Epub 2014 May 28. Mol Pharmacol. 2014. PMID: 24870406 Free article.

8

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases.

Christiansen E, Watterson KR, Stocker CJ, Sokol E, Jenkins L, Simon K, Grundmann M, Petersen RK, Wargent ET, Hudson BD, Kostenis E, Ejsing CS, Cawthorne MA, Milligan G, Ulven T. Christiansen E, et al. Among authors: jenkins l. Br J Nutr. 2015 Jun 14;113(11):1677-88. doi: 10.1017/S000711451500118X. Epub 2015 Apr 28. Br J Nutr. 2015. PMID: 25916176 Free article.

9

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E. Schrage R, et al. Among authors: jenkins l. Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156. Nat Commun. 2015. PMID: 26658454 Free PMC article.

10

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.

Mahmud ZA, Jenkins L, Ulven T, Labéguère F, Gosmini R, De Vos S, Hudson BD, Tikhonova IG, Milligan G. Mahmud ZA, et al. Among authors: jenkins l. Sci Rep. 2017 Dec 20;7(1):17953. doi: 10.1038/s41598-017-18159-3. Sci Rep. 2017. PMID: 29263400 Free PMC article.

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