Haak AJ - Search Results

1

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD. Bell JL, et al. Among authors: haak aj. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. doi: 10.1016/j.bmcl.2013.04.080. Epub 2013 May 7. Bioorg Med Chem Lett. 2013. PMID: 23707258 Free PMC article.

2

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.

Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD. Bell JL, et al. Among authors: haak aj. Beilstein J Org Chem. 2013 May 21;9:966-73. doi: 10.3762/bjoc.9.111. Print 2013. Beilstein J Org Chem. 2013. PMID: 23766813 Free PMC article.

3

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.

Johnson LA, Rodansky ES, Haak AJ, Larsen SD, Neubig RR, Higgins PD. Johnson LA, et al. Among authors: haak aj. Inflamm Bowel Dis. 2014 Jan;20(1):154-65. doi: 10.1097/01.MIB.0000437615.98881.31. Inflamm Bowel Dis. 2014. PMID: 24280883 Free PMC article.

4

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR. Haak AJ, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4. J Pharmacol Exp Ther. 2014. PMID: 24706986 Free PMC article.

5

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR. Haak AJ, et al. Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11. Mol Cancer Ther. 2017. PMID: 27837031 Free PMC article.

6

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.

Kahl DJ, Hutchings KM, Lisabeth EM, Haak AJ, Leipprandt JR, Dexheimer T, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD. Kahl DJ, et al. Among authors: haak aj. J Med Chem. 2019 May 9;62(9):4350-4369. doi: 10.1021/acs.jmedchem.8b01772. Epub 2019 Apr 18. J Med Chem. 2019. PMID: 30951312 Free PMC article.

7

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR. Evelyn CR, et al. Among authors: haak aj. Microarrays (Basel). 2016 May 28;5(2):13. doi: 10.3390/microarrays5020013. Microarrays (Basel). 2016. PMID: 27600078 Free PMC article.

8

Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.

Tsou PS, Haak AJ, Khanna D, Neubig RR. Tsou PS, et al. Among authors: haak aj. Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C2-13. doi: 10.1152/ajpcell.00060.2014. Epub 2014 Apr 16. Am J Physiol Cell Physiol. 2014. PMID: 24740541 Free PMC article. Review.

9

The role of HTS in drug discovery at the University of Michigan.

Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH. Larsen MJ, et al. Comb Chem High Throughput Screen. 2014 Mar;17(3):210-30. doi: 10.2174/1386207317666140109121546. Comb Chem High Throughput Screen. 2014. PMID: 24409957 Free PMC article. Review.

10

Regulator of G protein signaling 2 inhibits Gα_q-dependent uveal melanoma cell growth.

Zhang Q, Haak AJ, Sjögren B. Zhang Q, et al. Among authors: haak aj. J Biol Chem. 2022 Jun;298(6):101955. doi: 10.1016/j.jbc.2022.101955. Epub 2022 Apr 19. J Biol Chem. 2022. PMID: 35452684 Free PMC article.

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