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Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.
Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST. Figueiredo CP, et al. Among authors: klein wl. J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013. J Neurosci. 2013. PMID: 23739959 Free PMC article.
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. Bomfim TR, et al. Among authors: klein wl. J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256. J Clin Invest. 2012. PMID: 22476196 Free PMC article.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. Lourenco MV, et al. Among authors: klein wl. Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002. Cell Metab. 2013. PMID: 24315369 Free article.
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Forny-Germano L, et al. Among authors: klein wl. J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014. J Neurosci. 2014. PMID: 25297091 Free PMC article.
Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.
Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra E Silva NM, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alves-Leon S, Marcondes J, Assirati JA Jr, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A. Mendes ND, et al. Among authors: klein wl. J Neurosci Methods. 2018 Sep 1;307:203-209. doi: 10.1016/j.jneumeth.2018.05.021. Epub 2018 May 31. J Neurosci Methods. 2018. PMID: 29859877
181 results