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The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice.
Llanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J, Hidalgo C, Jaimovich E. Llanos P, et al. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E294-305. doi: 10.1152/ajpendo.00189.2014. Epub 2014 Dec 9. Am J Physiol Endocrinol Metab. 2015. PMID: 25491723 Free article.
Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.
Li Q, Zhu X, Ishikura S, Zhang D, Gao J, Sun Y, Contreras-Ferrat A, Foley KP, Lavandero S, Yao Z, Bilan PJ, Klip A, Niu W. Li Q, et al. Am J Physiol Endocrinol Metab. 2014 Jul 15;307(2):E209-24. doi: 10.1152/ajpendo.00045.2014. Epub 2014 Jun 3. Am J Physiol Endocrinol Metab. 2014. PMID: 24895284 Free article.
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake.
del Campo A, Parra V, Vásquez-Trincado C, Gutiérrez T, Morales PE, López-Crisosto C, Bravo-Sagua R, Navarro-Marquez MF, Verdejo HE, Contreras-Ferrat A, Troncoso R, Chiong M, Lavandero S. del Campo A, et al. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E1-E13. doi: 10.1152/ajpendo.00146.2013. Epub 2013 Oct 1. Am J Physiol Endocrinol Metab. 2014. PMID: 24085037 Free article.
Calcium signaling in insulin action on striated muscle.
Contreras-Ferrat A, Lavandero S, Jaimovich E, Klip A. Contreras-Ferrat A, et al. Cell Calcium. 2014 Nov;56(5):390-6. doi: 10.1016/j.ceca.2014.08.012. Epub 2014 Sep 6. Cell Calcium. 2014. PMID: 25224502 Review.
27 results