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Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR. Moujalled D, et al. Among authors: parker sj. PLoS One. 2013 Jun 26;8(6):e67433. doi: 10.1371/journal.pone.0067433. Print 2013. PLoS One. 2013. PMID: 23840699 Free PMC article.
Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.
Parker SJ, Meyerowitz J, James JL, Liddell JR, Nonaka T, Hasegawa M, Kanninen KM, Lim S, Paterson BM, Donnelly PS, Crouch PJ, White AR. Parker SJ, et al. PLoS One. 2012;7(8):e42277. doi: 10.1371/journal.pone.0042277. Epub 2012 Aug 3. PLoS One. 2012. PMID: 22879928 Free PMC article.
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Moujalled D, James JL, Yang S, Zhang K, Duncan C, Moujalled DM, Parker SJ, Caragounis A, Lidgerwood G, Turner BJ, Atkin JD, Grubman A, Liddell JR, Proepper C, Boeckers TM, Kanninen KM, Blair I, Crouch PJ, White AR. Moujalled D, et al. Among authors: parker sj. Hum Mol Genet. 2015 Mar 15;24(6):1655-69. doi: 10.1093/hmg/ddu578. Epub 2014 Nov 19. Hum Mol Genet. 2015. PMID: 25410660
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
Crouch PJ, Savva MS, Hung LW, Donnelly PS, Mot AI, Parker SJ, Greenough MA, Volitakis I, Adlard PA, Cherny RA, Masters CL, Bush AI, Barnham KJ, White AR. Crouch PJ, et al. Among authors: parker sj. J Neurochem. 2011 Oct;119(1):220-30. doi: 10.1111/j.1471-4159.2011.07402.x. Epub 2011 Aug 25. J Neurochem. 2011. PMID: 21797865 Free article.
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR. Kanninen KM, et al. Among authors: parker sj. PLoS One. 2013;8(3):e58644. doi: 10.1371/journal.pone.0058644. Epub 2013 Mar 14. PLoS One. 2013. PMID: 23516525 Free PMC article.
Copper modulates the large dense core vesicle secretory pathway in PC12 cells.
Duncan C, Bica L, Crouch PJ, Caragounis A, Lidgerwood GE, Parker SJ, Meyerowitz J, Volitakis I, Liddell JR, Raghupathi R, Paterson BM, Duffield MD, Cappai R, Donnelly PS, Grubman A, Camakaris J, Keating DJ, White AR. Duncan C, et al. Among authors: parker sj. Metallomics. 2013 Jun;5(6):700-14. doi: 10.1039/c3mt20231c. Metallomics. 2013. PMID: 23661118
180 results