Di L - Search Results

1

In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method.

Di L, Atkinson K, Orozco CC, Funk C, Zhang H, McDonald TS, Tan B, Lin J, Chang C, Obach RS. Di L, et al. Drug Metab Dispos. 2013 Dec;41(12):2018-23. doi: 10.1124/dmd.113.053322. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857891

2

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Di L, et al. Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7. Drug Metab Dispos. 2011. PMID: 21474681

3

Development of a new permeability assay using low-efflux MDCKII cells.

Di L, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ 3rd, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, Kempshall S, Fenner K, El-Kattan AF, Liston TE, Troutman MD. Di L, et al. J Pharm Sci. 2011 Nov;100(11):4974-85. doi: 10.1002/jps.22674. Epub 2011 Jul 15. J Pharm Sci. 2011. PMID: 21766308

4

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

Varma MV, Gardner I, Steyn SJ, Nkansah P, Rotter CJ, Whitney-Pickett C, Zhang H, Di L, Cram M, Fenner KS, El-Kattan AF. Varma MV, et al. Among authors: di l. Mol Pharm. 2012 May 7;9(5):1199-212. doi: 10.1021/mp2004912. Epub 2012 Apr 26. Mol Pharm. 2012. PMID: 22489626

5

A novel relay method for determining low-clearance values.

Di L, Trapa P, Obach RS, Atkinson K, Bi YA, Wolford AC, Tan B, McDonald TS, Lai Y, Tremaine LM. Di L, et al. Drug Metab Dispos. 2012 Sep;40(9):1860-5. doi: 10.1124/dmd.112.046425. Epub 2012 May 29. Drug Metab Dispos. 2012. PMID: 22645091

6

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

7

Statistical methods for analysis of time-dependent inhibition of cytochrome p450 enzymes.

Yates P, Eng H, Di L, Obach RS. Yates P, et al. Among authors: di l. Drug Metab Dispos. 2012 Dec;40(12):2289-96. doi: 10.1124/dmd.112.047233. Epub 2012 Aug 31. Drug Metab Dispos. 2012. PMID: 22942318

8

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.

Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Fu C, et al. Among authors: di l. Drug Metab Dispos. 2013 Oct;41(10):1797-804. doi: 10.1124/dmd.113.053082. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857892

9

A perspective on the prediction of drug pharmacokinetics and disposition in drug research and development.

Di L, Feng B, Goosen TC, Lai Y, Steyn SJ, Varma MV, Obach RS. Di L, et al. Drug Metab Dispos. 2013 Dec;41(12):1975-93. doi: 10.1124/dmd.113.054031. Epub 2013 Sep 24. Drug Metab Dispos. 2013. PMID: 24065860

10

The role of drug metabolizing enzymes in clearance.

Di L. Di L. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):379-93. doi: 10.1517/17425255.2014.876006. Epub 2014 Jan 7. Expert Opin Drug Metab Toxicol. 2014. PMID: 24392841 Review.

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