Helin K - Search Results

1

Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation.

Malatesta M, Steinhauer C, Mohammad F, Pandey DP, Squatrito M, Helin K. Malatesta M, et al. Among authors: helin k. Cancer Res. 2013 Oct 15;73(20):6323-33. doi: 10.1158/0008-5472.CAN-12-4660. Epub 2013 Aug 13. Cancer Res. 2013. PMID: 23943798

2

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.

Pasini D, Malatesta M, Jung HR, Walfridsson J, Willer A, Olsson L, Skotte J, Wutz A, Porse B, Jensen ON, Helin K. Pasini D, et al. Among authors: helin k. Nucleic Acids Res. 2010 Aug;38(15):4958-69. doi: 10.1093/nar/gkq244. Epub 2010 Apr 12. Nucleic Acids Res. 2010. PMID: 20385584 Free PMC article.

3

The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors.

Hudlebusch HR, Santoni-Rugiu E, Simon R, Ralfkiær E, Rossing HH, Johansen JV, Jørgensen M, Sauter G, Helin K. Hudlebusch HR, et al. Among authors: helin k. Clin Cancer Res. 2011 May 1;17(9):2919-33. doi: 10.1158/1078-0432.CCR-10-1302. Epub 2011 Mar 8. Clin Cancer Res. 2011. PMID: 21385930

4

MMSET is highly expressed and associated with aggressiveness in neuroblastoma.

Hudlebusch HR, Skotte J, Santoni-Rugiu E, Zimling ZG, Lees MJ, Simon R, Sauter G, Rota R, De Ioris MA, Quarto M, Johansen JV, Jørgensen M, Rechnitzer C, Maroun LL, Schrøder H, Petersen BL, Helin K. Hudlebusch HR, et al. Among authors: helin k. Cancer Res. 2011 Jun 15;71(12):4226-35. doi: 10.1158/0008-5472.CAN-10-3810. Epub 2011 Apr 28. Cancer Res. 2011. PMID: 21527557

5

Jarid1b targets genes regulating development and is involved in neural differentiation.

Schmitz SU, Albert M, Malatesta M, Morey L, Johansen JV, Bak M, Tommerup N, Abarrategui I, Helin K. Schmitz SU, et al. Among authors: helin k. EMBO J. 2011 Nov 16;30(22):4586-600. doi: 10.1038/emboj.2011.383. EMBO J. 2011. PMID: 22020125 Free PMC article.

6

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.

Arteaga MF, Mikesch JH, Qiu J, Christensen J, Helin K, Kogan SC, Dong S, So CW. Arteaga MF, et al. Among authors: helin k. Cancer Cell. 2013 Mar 18;23(3):376-89. doi: 10.1016/j.ccr.2013.02.014. Cancer Cell. 2013. PMID: 23518351 Free PMC article.

7

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

Albert M, Schmitz SU, Kooistra SM, Malatesta M, Morales Torres C, Rekling JC, Johansen JV, Abarrategui I, Helin K. Albert M, et al. Among authors: helin k. PLoS Genet. 2013 Apr;9(4):e1003461. doi: 10.1371/journal.pgen.1003461. Epub 2013 Apr 18. PLoS Genet. 2013. PMID: 23637629 Free PMC article.

8

A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence.

Kooistra SM, Nørgaard LC, Lees MJ, Steinhauer C, Johansen JV, Helin K. Kooistra SM, et al. Among authors: helin k. PLoS One. 2014 Mar 20;9(3):e91034. doi: 10.1371/journal.pone.0091034. eCollection 2014. PLoS One. 2014. PMID: 24651706 Free PMC article.

9

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.

Comet I, Riising EM, Leblanc B, Helin K. Comet I, et al. Among authors: helin k. Nat Rev Cancer. 2016 Dec;16(12):803-810. doi: 10.1038/nrc.2016.83. Epub 2016 Sep 23. Nat Rev Cancer. 2016. PMID: 27658528 Review.

10

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.

Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K. Mohammad F, et al. Among authors: helin k. Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27. Nat Med. 2017. PMID: 28263309

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