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Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE. Correia B, et al. Among authors: kaye km. PLoS Pathog. 2013;9(10):e1003673. doi: 10.1371/journal.ppat.1003673. Epub 2013 Oct 17. PLoS Pathog. 2013. PMID: 24146618 Free PMC article.
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE. Ponnusamy R, et al. Among authors: kaye km. Nucleic Acids Res. 2015 Nov 16;43(20):10039-54. doi: 10.1093/nar/gkv987. Epub 2015 Sep 30. Nucleic Acids Res. 2015. PMID: 26424851 Free PMC article.
KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence.
Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, Liu B, Álvarez ÁL, Tan M, Szymula A, Kaye KM, Simas JP. Juillard F, et al. Among authors: kaye km. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22443-22451. doi: 10.1073/pnas.2004809117. Epub 2020 Aug 20. Proc Natl Acad Sci U S A. 2020. PMID: 32820070 Free PMC article.
MLL1 is regulated by KSHV LANA and is important for virus latency.
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM. Tan M, et al. Among authors: kaye km. Nucleic Acids Res. 2021 Dec 16;49(22):12895-12911. doi: 10.1093/nar/gkab1094. Nucleic Acids Res. 2021. PMID: 34850113 Free PMC article.
80 results