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Page 1
Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists.
Penning TD, Khilevich A, Chen BB, Russell MA, Boys ML, Wang Y, Duffin T, Engleman VW, Finn MB, Freeman SK, Hanneke ML, Keene JL, Klover JA, Nickols GA, Nickols MA, Rader RK, Settle SL, Shannon KE, Steininger CN, Westlin MM, Westlin WF. Penning TD, et al. Among authors: chen bb. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3156-61. doi: 10.1016/j.bmcl.2006.03.045. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621534
Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists.
Penning TD, Russell MA, Chen BB, Chen HY, Desai BN, Docter SH, Edwards DJ, Gesicki GJ, Liang CD, Malecha JW, Yu SS, Engleman VW, Freeman SK, Hanneke ML, Shannon KE, Westlin MM, Nickols GA. Penning TD, et al. Among authors: chen bb, chen hy. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1471-6. doi: 10.1016/j.bmcl.2004.01.015. Bioorg Med Chem Lett. 2004. PMID: 15006384
Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.
Penning TD, Russell MA, Chen BB, Chen HY, Liang CD, Mahoney MW, Malecha JW, Miyashiro JM, Yu SS, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG. Penning TD, et al. Among authors: chen bb, chen hy. J Med Chem. 2002 Aug 1;45(16):3482-90. doi: 10.1021/jm0200916. J Med Chem. 2002. PMID: 12139459
Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists.
Boys ML, Schretzman LA, Chandrakumar NS, Tollefson MB, Mohler SB, Downs VL, Penning TD, Russell MA, Wendt JA, Chen BB, Stenmark HG, Wu H, Spangler DP, Clare M, Desai BN, Khanna IK, Nguyen MN, Duffin T, Engleman VW, Finn MB, Freeman SK, Hanneke ML, Keene JL, Klover JA, Nickols GA, Nickols MA, Steininger CN, Westlin M, Westlin W, Yu YX, Wang Y, Dalton CR, Norring SA. Boys ML, et al. Among authors: chen bb. Bioorg Med Chem Lett. 2006 Feb 15;16(4):839-44. doi: 10.1016/j.bmcl.2005.11.008. Epub 2005 Nov 17. Bioorg Med Chem Lett. 2006. PMID: 16298127
Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.
Nagarajan SR, Lu HF, Gasiecki AF, Khanna IK, Parikh MD, Desai BN, Rogers TE, Clare M, Chen BB, Russell MA, Keene JL, Duffin T, Engleman VW, Finn MB, Freeman SK, Klover JA, Nickols GA, Nickols MA, Shannon KE, Steininger CA, Westlin WF, Westlin MM, Williams ML. Nagarajan SR, et al. Among authors: chen bb. Bioorg Med Chem. 2007 May 15;15(10):3390-412. doi: 10.1016/j.bmc.2007.03.020. Epub 2007 Mar 13. Bioorg Med Chem. 2007. PMID: 17387018
Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties.
Wendt JA, Wu H, Stenmark HG, Boys ML, Downs VL, Penning TD, Chen BB, Wang Y, Duffin T, Finn MB, Keene JL, Engleman VW, Freeman SK, Hanneke ML, Shannon KE, Nickols MA, Steininger CN, Westlin M, Klover JA, Westlin W, Nickols GA, Russell MA. Wendt JA, et al. Among authors: chen bb. Bioorg Med Chem Lett. 2006 Feb 15;16(4):845-9. doi: 10.1016/j.bmcl.2005.11.017. Epub 2005 Nov 21. Bioorg Med Chem Lett. 2006. PMID: 16303301
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM, Russell MA, Yu SS, Corley DG, Durley RC, Kilpatrick BF, Parnas BL, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Krivi GG, Villani-Price D, Pyla EY, Smith WG. Penning TD, et al. Among authors: chen bb, chen hy. J Med Chem. 2000 Feb 24;43(4):721-35. doi: 10.1021/jm990496z. J Med Chem. 2000. PMID: 10691697
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