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Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.
Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M. Maruyama M, et al. Among authors: takashima a. Neuron. 2013 Sep 18;79(6):1094-108. doi: 10.1016/j.neuron.2013.07.037. Neuron. 2013. PMID: 24050400 Free PMC article.
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, Arai H. Fujiwara H, et al. Among authors: takashima a. J Neurochem. 2009 Jun;109(6):1648-57. doi: 10.1111/j.1471-4159.2009.06069.x. Epub 2009 May 7. J Neurochem. 2009. PMID: 19457098 Free article.
Aluminum induces tau aggregation in vitro but not in vivo.
Mizoroki T, Meshitsuka S, Maeda S, Murayama M, Sahara N, Takashima A. Mizoroki T, et al. Among authors: takashima a. J Alzheimers Dis. 2007 Jul;11(4):419-27. doi: 10.3233/jad-2007-11401. J Alzheimers Dis. 2007. PMID: 17656819
Novel conformation-sensitive antibodies specific to three- and four-repeat tau.
Ueno H, Murayama O, Maeda S, Sahara N, Park JM, Murayama M, Sanda A, Iwahashi K, Matsuda M, Takashima A. Ueno H, et al. Among authors: takashima a. Biochem Biophys Res Commun. 2007 Jun 29;358(2):602-7. doi: 10.1016/j.bbrc.2007.04.176. Epub 2007 May 4. Biochem Biophys Res Commun. 2007. PMID: 17493585
In vivo evidence of CHIP up-regulation attenuating tau aggregation.
Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y, Takahashi R, Murata S, Tanaka K, Takashima A. Sahara N, et al. Among authors: takashima a. J Neurochem. 2005 Sep;94(5):1254-63. doi: 10.1111/j.1471-4159.2005.03272.x. J Neurochem. 2005. PMID: 16111477 Free article.
735 results