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Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction.
Laeremans H, Hackeng TM, van Zandvoort MA, Thijssen VL, Janssen BJ, Ottenheijm HC, Smits JF, Blankesteijn WM. Laeremans H, et al. Among authors: ottenheijm hc. Circulation. 2011 Oct 11;124(15):1626-35. doi: 10.1161/CIRCULATIONAHA.110.976969. Epub 2011 Sep 19. Circulation. 2011. PMID: 21931076 Free article.
Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.
Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ. Roumen L, et al. Among authors: ottenheijm hc. J Comput Chem. 2011 Aug;32(11):2441-8. doi: 10.1002/jcc.21827. Epub 2011 May 19. J Comput Chem. 2011. PMID: 21598279
Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).
Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ. Roumen L, et al. Among authors: ottenheijm hc. J Med Chem. 2010 Feb 25;53(4):1712-25. doi: 10.1021/jm901356d. J Med Chem. 2010. PMID: 20121113
Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.
Minnaard-Huiban M, Emmen JM, Roumen L, Beugels IP, Cohuet GM, van Essen H, Ruijters E, Pieterse K, Hilbers PA, Ottenheijm HC, Plate R, de Gooyer ME, Smits JF, Hermans JJ. Minnaard-Huiban M, et al. Among authors: ottenheijm hc. Endocrinology. 2008 Jan;149(1):28-31. doi: 10.1210/en.2007-0584. Epub 2007 Sep 20. Endocrinology. 2008. PMID: 17884944
45 results