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Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.
Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS. Werminghaus P, et al. Among authors: willenberg hs. J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21. J Steroid Biochem Mol Biol. 2014. PMID: 24063979
Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway.
Schinner S, Willenberg HS, Krause D, Schott M, Lamounier-Zepter V, Krug AW, Ehrhart-Bornstein M, Bornstein SR, Scherbaum WA. Schinner S, et al. Among authors: willenberg hs. Int J Obes (Lond). 2007 May;31(5):864-70. doi: 10.1038/sj.ijo.0803508. Epub 2007 Jan 9. Int J Obes (Lond). 2007. PMID: 17211444
164 results