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Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.
Dowman JK, Hopkins LJ, Reynolds GM, Armstrong MJ, Nasiri M, Nikolaou N, van Houten EL, Visser JA, Morgan SA, Lavery GG, Oprescu A, Hübscher SG, Newsome PN, Tomlinson JW. Dowman JK, et al. Among authors: lavery gg. Endocrinology. 2013 Dec;154(12):4536-47. doi: 10.1210/en.2013-1592. Epub 2013 Sep 30. Endocrinology. 2013. PMID: 24080367 Free PMC article.
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM. Draper N, et al. Among authors: lavery gg. Nat Genet. 2003 Aug;34(4):434-9. doi: 10.1038/ng1214. Nat Genet. 2003. PMID: 12858176
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.
Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CHL, McKiernan P, Elias E, Chou JY, Stewart PM. Walker EA, et al. Among authors: lavery gg. J Biol Chem. 2007 Sep 14;282(37):27030-27036. doi: 10.1074/jbc.M704144200. Epub 2007 Jun 22. J Biol Chem. 2007. PMID: 17588937 Free article.
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
Lavery GG, Walker EA, Tiganescu A, Ride JP, Shackleton CH, Tomlinson JW, Connell JM, Ray DW, Biason-Lauber A, Malunowicz EM, Arlt W, Stewart PM. Lavery GG, et al. J Clin Endocrinol Metab. 2008 Oct;93(10):3827-32. doi: 10.1210/jc.2008-0743. Epub 2008 Jul 15. J Clin Endocrinol Metab. 2008. PMID: 18628520 Free PMC article.
Biochemistry and physiology of hexose-6-phosphate knockout mice.
Zielinska AE, Walker EA, Stewart PM, Lavery GG. Zielinska AE, et al. Among authors: lavery gg. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):213-8. doi: 10.1016/j.mce.2010.12.004. Epub 2010 Dec 10. Mol Cell Endocrinol. 2011. PMID: 21146583 Review.
161 results