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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.
Aleo MD, Aubrecht J, D Bonin P, Burt DA, Colangelo J, Luo L, Schomaker S, Swiss R, Kirby S, C Rigdon G, Dua P. Aleo MD, et al. Pharmacol Res Perspect. 2019 Feb;7(1):e00467. doi: 10.1002/prp2.467. Pharmacol Res Perspect. 2019. PMID: 30784208 Free PMC article. Clinical Trial.
Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.
Criswell KA, Cook JC, Morse D, Lawton M, Somps C, Obert L, Roy M, Sokolowski S, Koza-Taylor P, Colangelo J, Navetta K, Brady J, Pegg D, Wojcinski Z, Rahbari R, Duddy S, Anderson T. Criswell KA, et al. Toxicol Sci. 2012 Jul;128(1):42-56. doi: 10.1093/toxsci/kfs148. Epub 2012 Apr 26. Toxicol Sci. 2012. PMID: 22539613
Current Practices and Challenges in Method Validation.
Poitout F, Colangelo JL, Lavallée S, Aulbach AD, Piché MS, Ennulat D, Ameri M, Boone LI. Poitout F, et al. Among authors: colangelo jl. Toxicol Pathol. 2018 Oct;46(7):847-856. doi: 10.1177/0192623318801571. Epub 2018 Sep 25. Toxicol Pathol. 2018. PMID: 30253718
[No title available]
[No authors listed] [No authors listed] PMID: 31962992
Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption.
Johnson K, Levine K, Sergi J, Chamoun J, Roach R, Vekich J, Favis M, Horn M, Cao X, Miller B, Snyder W, Aivazian D, Reagan W, Berryman E, Colangelo J, Markiewicz V, Bagi CM, Brown TP, Coyle A, Mohammadi M, Magram J. Johnson K, et al. J Bone Miner Res. 2017 Oct;32(10):2062-2073. doi: 10.1002/jbmr.3197. Epub 2017 Aug 25. J Bone Miner Res. 2017. PMID: 28600887 Free PMC article.
12 results