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Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.
Mukhopadhyay P, Rajesh M, Cao Z, Horváth B, Park O, Wang H, Erdelyi K, Holovac E, Wang Y, Liaudet L, Hamdaoui N, Lafdil F, Haskó G, Szabo C, Boulares AH, Gao B, Pacher P. Mukhopadhyay P, et al. Among authors: holovac e. Hepatology. 2014 May;59(5):1998-2009. doi: 10.1002/hep.26763. Epub 2014 Apr 1. Hepatology. 2014. PMID: 24089324 Free PMC article.
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Boulares AH, Auwerx J, Gao B, Pacher P. Mukhopadhyay P, et al. Among authors: holovac e. J Hepatol. 2017 Mar;66(3):589-600. doi: 10.1016/j.jhep.2016.10.023. Epub 2016 Oct 29. J Hepatol. 2017. PMID: 27984176
Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants.
Mukhopadhyay P, Horváth B, Zsengellėr Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdėlyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P. Mukhopadhyay P, et al. Among authors: holovac e. Free Radic Biol Med. 2012 Sep 1;53(5):1123-38. doi: 10.1016/j.freeradbiomed.2012.05.036. Epub 2012 Jun 6. Free Radic Biol Med. 2012. PMID: 22683818 Free PMC article.
Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy.
Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P. Mukhopadhyay P, et al. Among authors: holovac e. Free Radic Biol Med. 2012 Jan 15;52(2):497-506. doi: 10.1016/j.freeradbiomed.2011.11.001. Epub 2011 Nov 10. Free Radic Biol Med. 2012. PMID: 22120494 Free PMC article.
Zanubrutinib in Mantle Cell Lymphoma Management: A Comprehensive Review.
Alsuhebany N, Pan C, Holovac E, Do B, McBride A. Alsuhebany N, et al. Among authors: holovac e. Blood Lymphat Cancer. 2023 Nov 24;13:67-76. doi: 10.2147/BLCTT.S426588. eCollection 2023. Blood Lymphat Cancer. 2023. PMID: 38034984 Free PMC article. Review.