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Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization.
Underhaug J, Koldsø H, Runager K, Nielsen JT, Sørensen CS, Kristensen T, Otzen DE, Karring H, Malmendal A, Schiøtt B, Enghild JJ, Nielsen NC. Underhaug J, et al. Among authors: nielsen jt, nielsen nc. Biochim Biophys Acta. 2013 Dec;1834(12):2812-22. doi: 10.1016/j.bbapap.2013.10.008. Epub 2013 Oct 12. Biochim Biophys Acta. 2013. PMID: 24129074 Free PMC article.
Purification, crystallization and preliminary X-ray diffraction of wild-type and mutant recombinant human transforming growth factor beta-induced protein (TGFBIp).
Runager K, García-Castellanos R, Valnickova Z, Kristensen T, Nielsen NC, Klintworth GK, Gomis-Rüth FX, Enghild JJ. Runager K, et al. Among authors: nielsen nc. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):299-303. doi: 10.1107/S1744309109005016. Epub 2009 Feb 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19255489 Free PMC article.
Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp.
Runager K, Basaiawmoit RV, Deva T, Andreasen M, Valnickova Z, Sørensen CS, Karring H, Thøgersen IB, Christiansen G, Underhaug J, Kristensen T, Nielsen NC, Klintworth GK, Otzen DE, Enghild JJ. Runager K, et al. Among authors: nielsen nc. J Biol Chem. 2011 Feb 18;286(7):4951-8. doi: 10.1074/jbc.M110.181099. Epub 2010 Dec 6. J Biol Chem. 2011. PMID: 21135107 Free PMC article.
Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.
Andreasen M, Nielsen SB, Runager K, Christiansen G, Nielsen NC, Enghild JJ, Otzen DE. Andreasen M, et al. Among authors: nielsen sb, nielsen nc. J Biol Chem. 2012 Oct 5;287(41):34730-42. doi: 10.1074/jbc.M112.379552. Epub 2012 Aug 14. J Biol Chem. 2012. PMID: 22893702 Free PMC article.
Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants.
Koldsø H, Andersen OJ, Nikolajsen CL, Scavenius C, Sørensen CS, Underhaug J, Runager K, Nielsen NC, Enghild JJ, Schiøtt B. Koldsø H, et al. Among authors: nielsen nc. Biochemistry. 2015 Sep 15;54(36):5546-56. doi: 10.1021/acs.biochem.5b00473. Epub 2015 Sep 2. Biochemistry. 2015. PMID: 26305369 Free PMC article.
Divorcing folding from function: how acylation affects the membrane-perturbing properties of an antimicrobial peptide.
Vad B, Thomsen LA, Bertelsen K, Franzmann M, Pedersen JM, Nielsen SB, Vosegaard T, Valnickova Z, Skrydstrup T, Enghild JJ, Wimmer R, Nielsen NC, Otzen DE. Vad B, et al. Among authors: nielsen sb, nielsen nc. Biochim Biophys Acta. 2010 Apr;1804(4):806-20. doi: 10.1016/j.bbapap.2009.12.006. Epub 2009 Dec 22. Biochim Biophys Acta. 2010. PMID: 20026432
Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone.
Andreasen M, Nielsen SB, Mittag T, Bjerring M, Nielsen JT, Zhang S, Nielsen EH, Jeppesen M, Christiansen G, Besenbacher F, Dong M, Nielsen NC, Skrydstrup T, Otzen DE. Andreasen M, et al. Among authors: nielsen sb, nielsen jt, nielsen nc, nielsen eh. Biochim Biophys Acta. 2012 Feb;1824(2):274-85. doi: 10.1016/j.bbapap.2011.10.014. Epub 2011 Oct 29. Biochim Biophys Acta. 2012. PMID: 22064122
Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant.
Calcutta A, Jessen CM, Behrens MA, Oliveira CL, Renart ML, González-Ros JM, Otzen DE, Pedersen JS, Malmendal A, Nielsen NC. Calcutta A, et al. Among authors: nielsen nc. Biochim Biophys Acta. 2012 Sep;1818(9):2290-301. doi: 10.1016/j.bbamem.2012.04.005. Epub 2012 Apr 14. Biochim Biophys Acta. 2012. PMID: 22525601 Free article.
336 results