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Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.
Kim MJ, Jeong ES, Park JS, Lee SJ, Ghim JL, Choi CS, Shin JG, Kim DH. Kim MJ, et al. Among authors: kim dh. Drug Metab Dispos. 2014 Jan;42(1):141-52. doi: 10.1124/dmd.113.053017. Epub 2013 Oct 29. Drug Metab Dispos. 2014. PMID: 24170778
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
Oh KS, Park SJ, Shinde DD, Shin JG, Kim DH. Oh KS, et al. Among authors: kim dh. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 1;895-896:56-64. doi: 10.1016/j.jchromb.2012.03.014. Epub 2012 Mar 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22483397
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