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The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.
Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. Hansen A, et al. Among authors: beck pl. PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013. PLoS One. 2013. PMID: 24278446 Free PMC article.
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.
Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hirota SA, et al. Among authors: beck pl. Gastroenterology. 2010 Jul;139(1):259-69.e3. doi: 10.1053/j.gastro.2010.03.045. Epub 2010 Mar 27. Gastroenterology. 2010. PMID: 20347817 Free PMC article.
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.
Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, Muruve DA. Vilaysane A, et al. Among authors: beck pl. J Am Soc Nephrol. 2010 Oct;21(10):1732-44. doi: 10.1681/ASN.2010020143. Epub 2010 Aug 5. J Am Soc Nephrol. 2010. PMID: 20688930 Free PMC article.
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.
Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL. Hirota SA, et al. Among authors: beck pl. Inflamm Bowel Dis. 2011 Jun;17(6):1359-72. doi: 10.1002/ibd.21478. Epub 2010 Sep 24. Inflamm Bowel Dis. 2011. PMID: 20872834 Free PMC article.
194 results