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Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL. Doherty JR, et al. Among authors: yang c. Cancer Res. 2014 Feb 1;74(3):908-20. doi: 10.1158/0008-5472.CAN-13-2034. Epub 2013 Nov 27. Cancer Res. 2014. PMID: 24285728 Free PMC article.
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.
Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP. Jeffers JR, et al. Among authors: yang c. Cancer Cell. 2003 Oct;4(4):321-8. doi: 10.1016/s1535-6108(03)00244-7. Cancer Cell. 2003. PMID: 14585359 Free article.
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.
Garrison SP, Jeffers JR, Yang C, Nilsson JA, Hall MA, Rehg JE, Yue W, Yu J, Zhang L, Onciu M, Sample JT, Cleveland JL, Zambetti GP. Garrison SP, et al. Among authors: yang c. Mol Cell Biol. 2008 Sep;28(17):5391-402. doi: 10.1128/MCB.00907-07. Epub 2008 Jun 23. Mol Cell Biol. 2008. PMID: 18573879 Free PMC article.
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