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VapD in Xylella fastidiosa Is a Thermostable Protein with Ribonuclease Activity.
Mendes JS, Santiago Ada S, Toledo MA, Rosselli-Murai LK, Favaro MT, Santos CA, Horta MA, Crucello A, Beloti LL, Romero F, Tasic L, de Souza AA, de Souza AP. Mendes JS, et al. PLoS One. 2015 Dec 22;10(12):e0145765. doi: 10.1371/journal.pone.0145765. eCollection 2015. PLoS One. 2015. PMID: 26694028 Free PMC article.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
de Souza Gama FH, Dutra LA, Hawgood M, Dos Reis CV, Serafim RAM, Ferreira MA Jr, Teodoro BVM, Takarada JE, Santiago AS, Balourdas DI, Nilsson AS, Urien B, Almeida VM, Gileadi C, Ramos PZ, Salmazo A, Vasconcelos SNS, Cunha MR, Mueller S, Knapp S, Massirer KB, Elkins JM, Gileadi O, Mascarello A, Lemmens BBLG, Guimarães CRW, Azevedo H, Couñago RM. de Souza Gama FH, et al. Among authors: santiago as. J Med Chem. 2024 Jun 13;67(11):8609-8629. doi: 10.1021/acs.jmedchem.3c02250. Epub 2024 May 23. J Med Chem. 2024. PMID: 38780468
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM. Takarada JE, et al. Among authors: santiago as. Bioorg Med Chem. 2024 Jan 15;98:117561. doi: 10.1016/j.bmc.2023.117561. Epub 2023 Dec 20. Bioorg Med Chem. 2024. PMID: 38157838 Free article.
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Eduful BJ, O'Byrne SN, Temme L, Asquith CRM, Liang Y, Picado A, Pilotte JR, Hossain MA, Wells CI, Zuercher WJ, Catta-Preta CMC, Zonzini Ramos P, Santiago AS, Couñago RM, Langendorf CG, Nay K, Oakhill JS, Pulliam TL, Lin C, Awad D, Willson TM, Frigo DE, Scott JW, Drewry DH. Eduful BJ, et al. Among authors: santiago as. J Med Chem. 2021 Aug 12;64(15):10849-10877. doi: 10.1021/acs.jmedchem.0c02274. Epub 2021 Jul 15. J Med Chem. 2021. PMID: 34264658 Free PMC article.
The Vacuolating Autotransporter Toxin (Vat) of Escherichia coli Causes Cell Cytoskeleton Changes and Produces Non-lysosomal Vacuole Formation in Bladder Epithelial Cells.
Díaz JM, Dozois CM, Avelar-González FJ, Hernández-Cuellar E, Pokharel P, de Santiago AS, Guerrero-Barrera AL. Díaz JM, et al. Among authors: de santiago as. Front Cell Infect Microbiol. 2020 Jun 26;10:299. doi: 10.3389/fcimb.2020.00299. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32670893 Free PMC article.
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