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Irinotecan disrupts tight junction proteins within the gut : implications for chemotherapy-induced gut toxicity.
Cancer Biol Ther. 2014 Feb;15(2):236-44. doi: 10.4161/cbt.27222. Epub 2013 Dec 6.
Cancer Biol Ther. 2014.
PMID: 24316664
Free PMC article.
Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report.
Coller JK, Bowen JM, Ball IA, Wardill HR, van Sebille YZ, Stansborough RL, Lightwala Z, Wignall A, Shirren J, Secombe K, Gibson RJ.
Coller JK, et al. Among authors: shirren j.
Cancer Chemother Pharmacol. 2017 Feb;79(2):431-434. doi: 10.1007/s00280-016-3223-3. Epub 2016 Dec 23.
Cancer Chemother Pharmacol. 2017.
PMID: 28011980
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Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model.
Gibson RJ, van Sebille YZA, Wardill HR, Wignall A, Shirren J, Ball IA, Williams N, Wanner K, Bowen JM.
Gibson RJ, et al. Among authors: shirren j.
Chemotherapy. 2018;63(5):284-292. doi: 10.1159/000495470. Epub 2019 Feb 7.
Chemotherapy. 2018.
PMID: 30731451
Free PMC article.
Clinical Trial.
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Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.
Secombe KR, Ball IA, Shirren J, Wignall AD, Keefe DM, Bowen JM.
Secombe KR, et al. Among authors: shirren j.
Breast Cancer. 2021 Jan;28(1):99-109. doi: 10.1007/s12282-020-01133-9. Epub 2020 Jul 18.
Breast Cancer. 2021.
PMID: 32683606
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Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model.
Secombe KR, Ball IA, Shirren J, Wignall AD, Finnie J, Keefe D, Avogadri-Connors F, Olek E, Martin D, Moran S, Bowen JM.
Secombe KR, et al. Among authors: shirren j.
Cancer Chemother Pharmacol. 2019 Mar;83(3):531-543. doi: 10.1007/s00280-018-3756-8. Epub 2018 Dec 10.
Cancer Chemother Pharmacol. 2019.
PMID: 30535958
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