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Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention.
Desphande A, Xia G, Boerma LJ, Vines KK, Atigadda VR, Lobo-Ruppert S, Grubbs CJ, Moeinpour FL, Smith CD, Christov K, Brouillette WJ, Muccio DD. Desphande A, et al. Among authors: vines kk. Bioorg Med Chem. 2014 Jan 1;22(1):178-85. doi: 10.1016/j.bmc.2013.11.039. Epub 2013 Dec 1. Bioorg Med Chem. 2014. PMID: 24359708 Free PMC article.
Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30).
Atigadda VR, Vines KK, Grubbs CJ, Hill DL, Beenken SL, Bland KI, Brouillette WJ, Muccio DD. Atigadda VR, et al. Among authors: vines kk. J Med Chem. 2003 Aug 14;46(17):3766-9. doi: 10.1021/jm030095q. J Med Chem. 2003. PMID: 12904083
Total syntheses of epothilones B and d.
Jung JC, Kache R, Vines KK, Zheng YS, Bijoy P, Valluri M, Avery MA. Jung JC, et al. Among authors: vines kk. J Org Chem. 2004 Dec 24;69(26):9269-84. doi: 10.1021/jo048742o. J Org Chem. 2004. PMID: 15609966