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Serine protease inhibitor kunitz-type 2 is downregulated in myelodysplastic syndromes and modulates cell-cell adhesion.
Roversi FM, Lopes MR, Machado-Neto JA, Longhini AL, Duarte Ada S, Baratti MO, Palodetto B, Corrocher FA, Pericole FV, Campos Pde M, Favaro P, Traina F, Saad ST. Roversi FM, et al. Among authors: palodetto b. Stem Cells Dev. 2014 May 15;23(10):1109-20. doi: 10.1089/scd.2013.0441. Epub 2014 Feb 18. Stem Cells Dev. 2014. PMID: 24410667 Free PMC article. Clinical Trial.
Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway.
Roversi FM, Pericole FV, Machado-Neto JA, da Silva Santos Duarte A, Longhini AL, Corrocher FA, Palodetto B, Ferro KP, Rosa RG, Baratti MO, Verjovski-Almeida S, Traina F, Molinari A, Botta M, Saad ST. Roversi FM, et al. Among authors: palodetto b. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):450-461. doi: 10.1016/j.bbadis.2016.11.013. Epub 2016 Nov 11. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27840303 Free article.
SEMA3A partially reverses VEGF effects through binding to neuropilin-1.
Palodetto B, da Silva Santos Duarte A, Rodrigues Lopes M, Adolfo Corrocher F, Roversi FM, Soares Niemann F, Priscila Vieira Ferro K, Leda Figueiredo Longhini A, Melo Campos P, Favaro P, Teresinha Olalla Saad S. Palodetto B, et al. Stem Cell Res. 2017 Jul;22:70-78. doi: 10.1016/j.scr.2017.05.012. Epub 2017 Jun 3. Stem Cell Res. 2017. PMID: 28636974 Free article.
MDR-1 and GST polymorphisms are involved in myelodysplasia progression.
Palodetto B, de Melo Campos P, Benites BD, de Lourdes Lopes Ferrari Chauffaille M, Velloso ED, Traina F, Saad ST. Palodetto B, et al. Leuk Res. 2013 Aug;37(8):970-3. doi: 10.1016/j.leukres.2013.04.024. Epub 2013 May 17. Leuk Res. 2013. PMID: 23684483 Free article.