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JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Delgado-Hernández R, Porto-Verdecia M, Ochoa-Rodríguez E, Verdecia-Reyes Y, Marin-Prida J, González-Durruthy M, Uyemura SA, Rodrigues FP, Curti C, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Eur J Pharmacol. 2014 Mar 5;726:57-65. doi: 10.1016/j.ejphar.2014.01.021. Eur J Pharmacol. 2014. PMID: 24462350 Free article.
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19. Neuropharmacology. 2014. PMID: 24953828
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against Ca²⁺-induced mitochondrial impairment.
Nuñez-Figueredo Y, Pardo-Andreu GL, Ramírez-Sánchez J, Delgado-Hernández R, Ochoa-Rodríguez E, Verdecia-Reyes Y, Naal Z, Muller AP, Portela LV, Souza DO. Nuñez-Figueredo Y, et al. Brain Res Bull. 2014 Oct;109:68-76. doi: 10.1016/j.brainresbull.2014.10.001. Epub 2014 Oct 13. Brain Res Bull. 2014. PMID: 25305343 Free article.
Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway.
Ramírez-Sánchez J, Simões Pires EN, Nuñez-Figueredo Y, Pardo-Andreu GL, Fonseca-Fonseca LA, Ruiz-Reyes A, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Souza DO, Salbego C. Ramírez-Sánchez J, et al. Neurochem Int. 2015 Nov;90:215-23. doi: 10.1016/j.neuint.2015.09.003. Epub 2015 Sep 8. Neurochem Int. 2015. PMID: 26361722
KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity.
Fonseca-Fonseca LA, Nuñez-Figueredo Y, Sánchez JR, Guerra MW, Ochoa-Rodríguez E, Verdecia-Reyes Y, Hernádez RD, Menezes-Filho NJ, Costa TCS, de Santana WA, Oliveira JL, Segura-Aguilar J, da Silva VDA, Costa SL. Fonseca-Fonseca LA, et al. Among authors: ochoa rodriguez e. Neurotox Res. 2019 Aug;36(2):279-291. doi: 10.1007/s12640-017-9851-5. Epub 2018 Jan 2. Neurotox Res. 2019. PMID: 29294239
JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain.
Ramírez-Sánchez J, Pires ENS, Meneghetti A, Hansel G, Nuñez-Figueredo Y, Pardo-Andreu GL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Salbego C, Souza DO. Ramírez-Sánchez J, et al. Among authors: ochoa rodriguez e. Mol Neurobiol. 2019 Jan;56(1):502-512. doi: 10.1007/s12035-018-1087-8. Epub 2018 May 3. Mol Neurobiol. 2019. PMID: 29725905
18 results