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ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.
Duewell P, Kisser U, Heckelsmiller K, Hoves S, Stoitzner P, Koernig S, Morelli AB, Clausen BE, Dauer M, Eigler A, Anz D, Bourquin C, Maraskovsky E, Endres S, Schnurr M. Duewell P, et al. Among authors: maraskovsky e. J Immunol. 2011 Jul 1;187(1):55-63. doi: 10.4049/jimmunol.1004114. Epub 2011 May 25. J Immunol. 2011. PMID: 21613613 Free PMC article.
ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway.
Wilson NS, Yang B, Morelli AB, Koernig S, Yang A, Loeser S, Airey D, Provan L, Hass P, Braley H, Couto S, Drane D, Boyle J, Belz GT, Ashkenazi A, Maraskovsky E. Wilson NS, et al. Among authors: maraskovsky e. Immunol Cell Biol. 2012 May;90(5):540-52. doi: 10.1038/icb.2011.71. Epub 2011 Sep 6. Immunol Cell Biol. 2012. PMID: 21894173 Free PMC article.
Combination of adjuvants: the future of vaccine design.
Mount A, Koernig S, Silva A, Drane D, Maraskovsky E, Morelli AB. Mount A, et al. Among authors: maraskovsky e. Expert Rev Vaccines. 2013 Jul;12(7):733-46. doi: 10.1586/14760584.2013.811185. Expert Rev Vaccines. 2013. PMID: 23885819 Review.
112 results