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Probing kinase activation and substrate specificity with an engineered monomeric IKK2.
Biochemistry. 2014 Apr 1;53(12):2064-73. doi: 10.1021/bi401551r. Epub 2014 Mar 18.
Biochemistry. 2014.
PMID: 24611898
Free PMC article.
The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity.
Shaul JD, Farina A, Huxford T.
Shaul JD, et al.
Biochem Biophys Res Commun. 2008 Sep 26;374(3):592-7. doi: 10.1016/j.bbrc.2008.07.082. Epub 2008 Jul 25.
Biochem Biophys Res Commun. 2008.
PMID: 18657515
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Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
Han W, Ma X, Balibar CJ, Baxter Rath CM, Benton B, Bermingham A, Casey F, Chie-Leon B, Cho MK, Frank AO, Frommlet A, Ho CM, Lee PS, Li M, Lingel A, Ma S, Merritt H, Ornelas E, De Pascale G, Prathapam R, Prosen KR, Rasper D, Ruzin A, Sawyer WS, Shaul J, Shen X, Shia S, Steffek M, Subramanian S, Vo J, Wang F, Wartchow C, Uehara T.
Han W, et al.
J Am Chem Soc. 2020 Mar 4;142(9):4445-4455. doi: 10.1021/jacs.9b13530. Epub 2020 Feb 17.
J Am Chem Soc. 2020.
PMID: 32064871
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Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.
Dean CR, Barkan DT, Bermingham A, Blais J, Casey F, Casarez A, Colvin R, Fuller J, Jones AK, Li C, Lopez S, Metzger LE 4th, Mostafavi M, Prathapam R, Rasper D, Reck F, Ruzin A, Shaul J, Shen X, Simmons RL, Skewes-Cox P, Takeoka KT, Tamrakar P, Uehara T, Wei JR.
Dean CR, et al.
Antimicrob Agents Chemother. 2018 Sep 24;62(10):e01200-18. doi: 10.1128/AAC.01200-18. Print 2018 Oct.
Antimicrob Agents Chemother. 2018.
PMID: 30061293
Free PMC article.
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Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
Reck F, Bermingham A, Blais J, Capka V, Cariaga T, Casarez A, Colvin R, Dean CR, Fekete A, Gong W, Growcott E, Guo H, Jones AK, Li C, Li F, Lin X, Lindvall M, Lopez S, McKenney D, Metzger L, Moser HE, Prathapam R, Rasper D, Rudewicz P, Sethuraman V, Shen X, Shaul J, Simmons RL, Tashiro K, Tang D, Tjandra M, Turner N, Uehara T, Vitt C, Whitebread S, Yifru A, Zang X, Zhu Q.
Reck F, et al.
Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755. doi: 10.1016/j.bmcl.2018.01.006. Epub 2018 Jan 4.
Bioorg Med Chem Lett. 2018.
PMID: 29336873
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IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor.
Reck F, Bermingham A, Blais J, Casarez A, Colvin R, Dean CR, Furegati M, Gamboa L, Growcott E, Li C, Lopez S, Metzger L, Nocito S, Ossola F, Phizackerley K, Rasper D, Shaul J, Shen X, Simmons RL, Tang D, Tashiro K, Yue Q.
Reck F, et al.
ACS Infect Dis. 2019 Jul 12;5(7):1045-1051. doi: 10.1021/acsinfecdis.9b00031. Epub 2019 Mar 27.
ACS Infect Dis. 2019.
PMID: 30861342
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A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses.
Kane JR, Fong S, Shaul J, Frommlet A, Frank AO, Knapp M, Bussiere DE, Kim P, Ornelas E, Cuellar C, Hyrina A, Abend JR, Wartchow CA.
Kane JR, et al.
Elife. 2020 Jan 21;9:e50722. doi: 10.7554/eLife.50722.
Elife. 2020.
PMID: 31960795
Free PMC article.
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Biochemical Characterization of Respiratory Syncytial Virus RNA-Dependent RNA Polymerase Complex.
Balakrishnan A, Price E, Luu C, Shaul J, Wartchow C, Cantwell J, Vo T, DiDonato M, Spraggon G, Hekmat-Nejad M.
Balakrishnan A, et al.
ACS Infect Dis. 2020 Oct 9;6(10):2800-2811. doi: 10.1021/acsinfecdis.0c00554. Epub 2020 Sep 22.
ACS Infect Dis. 2020.
PMID: 32886480
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