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The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.
Mol Oncol. 2014 May;8(3):728-40. doi: 10.1016/j.molonc.2014.02.003. Epub 2014 Feb 17.
Mol Oncol. 2014.
PMID: 24618081
Free PMC article.
The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation.
Toffalini F, Kallin A, Vandenberghe P, Pierre P, Michaux L, Cools J, Demoulin JB.
Toffalini F, et al.
Haematologica. 2009 Aug;94(8):1085-93. doi: 10.3324/haematol.2008.001149.
Haematologica. 2009.
PMID: 19644140
Free PMC article.
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Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.
Toffalini F, Hellberg C, Demoulin JB.
Toffalini F, et al.
J Biol Chem. 2010 Apr 16;285(16):12268-78. doi: 10.1074/jbc.M109.076638. Epub 2010 Feb 17.
J Biol Chem. 2010.
PMID: 20164181
Free PMC article.
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New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases.
Toffalini F, Demoulin JB.
Toffalini F, et al.
Blood. 2010 Oct 7;116(14):2429-37. doi: 10.1182/blood-2010-04-279752. Epub 2010 Jun 25.
Blood. 2010.
PMID: 20581310
Free article.
Review.
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Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data.
Essaghir A, Toffalini F, Knoops L, Kallin A, van Helden J, Demoulin JB.
Essaghir A, et al. Among authors: toffalini f.
Nucleic Acids Res. 2010 Jun;38(11):e120. doi: 10.1093/nar/gkq149. Epub 2010 Mar 9.
Nucleic Acids Res. 2010.
PMID: 20215436
Free PMC article.
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[Role of PDGF and FGF receptors in cancer].
Demoulin JB, Medves S, Toffalini F, Essaghir A, Kallin A, Montano C, Velghe A, Duhoux F.
Demoulin JB, et al. Among authors: toffalini f.
Bull Mem Acad R Med Belg. 2010;165(5-6):310-5.
Bull Mem Acad R Med Belg. 2010.
PMID: 21513119
French.
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KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia.
Medves S, Duhoux FP, Ferrant A, Toffalini F, Ameye G, Libouton JM, Poirel HA, Demoulin JB.
Medves S, et al. Among authors: toffalini f.
Leukemia. 2010 May;24(5):1052-5. doi: 10.1038/leu.2010.13. Epub 2010 Feb 18.
Leukemia. 2010.
PMID: 20164854
No abstract available.
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