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Page 1
AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.
Tuominen I, Heliövaara E, Raitila A, Rautiainen MR, Mehine M, Katainen R, Donner I, Aittomäki V, Lehtonen HJ, Ahlsten M, Kivipelto L, Schalin-Jäntti C, Arola J, Hautaniemi S, Karhu A. Tuominen I, et al. Among authors: ahlsten m. Oncogene. 2015 Feb 26;34(9):1174-84. doi: 10.1038/onc.2014.50. Epub 2014 Mar 24. Oncogene. 2015. PMID: 24662816
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.
Raitila A, Lehtonen HJ, Arola J, Heliövaara E, Ahlsten M, Georgitsi M, Jalanko A, Paetau A, Aaltonen LA, Karhu A. Raitila A, et al. Among authors: ahlsten m. Am J Pathol. 2010 Oct;177(4):1969-76. doi: 10.2353/ajpath.2010.100138. Epub 2010 Aug 13. Am J Pathol. 2010. PMID: 20709796 Free PMC article.
No evidence of RET germline mutations in familial pituitary adenoma.
Heliövaara E, Tuupanen S, Ahlsten M, Hodgson S, de Menis E, Kuismin O, Izatt L, McKinlay Gardner RJ, Gundogdu S, Lucassen A, Arola J, Tuomisto A, Mäkinen M, Karhu A, Aaltonen LA. Heliövaara E, et al. Among authors: ahlsten m. J Mol Endocrinol. 2010 Dec 21;46(1):1-8. doi: 10.1677/JME-10-0052. Print 2011 Feb. J Mol Endocrinol. 2010. PMID: 20956458