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A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.
Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP. Prime TA, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15. Proc Natl Acad Sci U S A. 2009. PMID: 19528654 Free PMC article.
MitoQ administration prevents endotoxin-induced cardiac dysfunction.
Supinski GS, Murphy MP, Callahan LA. Supinski GS, et al. Among authors: murphy mp. Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1095-102. doi: 10.1152/ajpregu.90902.2008. Epub 2009 Aug 5. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19657095 Free PMC article.
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.
Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP. Rodriguez-Cuenca S, et al. Among authors: murphy mp. Free Radic Biol Med. 2010 Jan 1;48(1):161-72. doi: 10.1016/j.freeradbiomed.2009.10.039. Epub 2009 Oct 23. Free Radic Biol Med. 2010. PMID: 19854266
794 results