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Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.
Wagener J, Malireddi RK, Lenardon MD, Köberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti TD, Brown GD, Brown AJ, Gow NA. Wagener J, et al. Among authors: lenardon md. PLoS Pathog. 2014 Apr 10;10(4):e1004050. doi: 10.1371/journal.ppat.1004050. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24722226 Free PMC article. Clinical Trial.
The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans.
Cheng SC, van de Veerdonk FL, Lenardon M, Stoffels M, Plantinga T, Smeekens S, Rizzetto L, Mukaremera L, Preechasuth K, Cavalieri D, Kanneganti TD, van der Meer JW, Kullberg BJ, Joosten LA, Gow NA, Netea MG. Cheng SC, et al. J Leukoc Biol. 2011 Aug;90(2):357-66. doi: 10.1189/jlb.1210702. Epub 2011 Apr 29. J Leukoc Biol. 2011. PMID: 21531876 Free PMC article.
Chitin synthesis and fungal pathogenesis.
Lenardon MD, Munro CA, Gow NA. Lenardon MD, et al. Curr Opin Microbiol. 2010 Aug;13(4):416-23. doi: 10.1016/j.mib.2010.05.002. Epub 2010 Jun 8. Curr Opin Microbiol. 2010. PMID: 20561815 Free PMC article. Review.
Recognition and blocking of innate immunity cells by Candida albicans chitin.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, Brown AJ, Munro CA, Gow NA. Mora-Montes HM, et al. Among authors: lenardon md. Infect Immun. 2011 May;79(5):1961-70. doi: 10.1128/IAI.01282-10. Epub 2011 Feb 28. Infect Immun. 2011. PMID: 21357722 Free PMC article.
Cell wall protection by the Candida albicans class I chitin synthases.
Preechasuth K, Anderson JC, Peck SC, Brown AJ, Gow NA, Lenardon MD. Preechasuth K, et al. Among authors: lenardon md. Fungal Genet Biol. 2015 Sep;82:264-76. doi: 10.1016/j.fgb.2015.08.001. Epub 2015 Aug 7. Fungal Genet Biol. 2015. PMID: 26257018 Free PMC article.
25 results