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Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike.
Scharf L, Scheid JF, Lee JH, West AP Jr, Chen C, Gao H, Gnanapragasam PN, Mares R, Seaman MS, Ward AB, Nussenzweig MC, Bjorkman PJ. Scharf L, et al. Among authors: gnanapragasam pn. Cell Rep. 2014 May 8;7(3):785-95. doi: 10.1016/j.celrep.2014.04.001. Epub 2014 Apr 24. Cell Rep. 2014. PMID: 24767986 Free PMC article.
Designed oligomers of cyanovirin-N show enhanced HIV neutralization.
Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL. Keeffe JR, et al. Among authors: gnanapragasam pn. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14079-84. doi: 10.1073/pnas.1108777108. Epub 2011 Jul 28. Proc Natl Acad Sci U S A. 2011. PMID: 21799112 Free PMC article.
Single-chain Fv-based anti-HIV proteins: potential and limitations.
West AP Jr, Galimidi RP, Gnanapragasam PN, Bjorkman PJ. West AP Jr, et al. Among authors: gnanapragasam pn. J Virol. 2012 Jan;86(1):195-202. doi: 10.1128/JVI.05848-11. Epub 2011 Oct 19. J Virol. 2012. PMID: 22013046 Free PMC article.
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.
Mouquet H, Scharf L, Euler Z, Liu Y, Eden C, Scheid JF, Halper-Stromberg A, Gnanapragasam PN, Spencer DI, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ. Mouquet H, et al. Among authors: gnanapragasam pn. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3268-77. doi: 10.1073/pnas.1217207109. Epub 2012 Oct 30. Proc Natl Acad Sci U S A. 2012. PMID: 23115339 Free PMC article.
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev IS, Pancera M, Zhou T, Incesu RB, Fu BZ, Gnanapragasam PN, Oliveira TY, Seaman MS, Kwong PD, Bjorkman PJ, Nussenzweig MC. Klein F, et al. Among authors: gnanapragasam pn. Cell. 2013 Mar 28;153(1):126-38. doi: 10.1016/j.cell.2013.03.018. Cell. 2013. PMID: 23540694 Free PMC article.
39 results